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Encyclopedia of Cancer pp 1–3Cite as

Pentakisphosphate

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Definition

Inositol pentakisphosphate (abbreviated IP5) is a molecule derived from inositol containing five phosphate groups and possessing anticancer properties.

Characteristics

Inositol Phosphate Family

Inositol is a polycyclic polyalcohol whose structure forms the backbone for all inositol polyphosphates (IPs) and phosphatidylinositol lipids (phospholipids). Over 30 different inositol polyphosphates have been identified so far in mammalian cells yet, despite their importance, the majority of these remain completely uncharacterized.

Many inositol derivatives play a key role in eukaryotic cells and are involved in a large number of biochemical processes mostly acting as second messengers in intracellular signaling. The best example is represented by inositol 1,4,5-trisphosphate (IP), which plays a very important role in many signaling pathways and also serves as a precursor for the synthesis of several highly phosphorylated inositol polyphosphates such as inositol tetrakisphosphate...

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References

  • Berrie CP, Falasca M (2000) Patterns within protein/polyphosphoinositide interactions provide specific targets for therapeutic intervention. FASEB J 15:2618–2622

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  • Maffucci T, Falasca M (2001) Specificity in pleckstrin homology (PH) domain membrane targeting: a role for a phosphoinositide-protein co-operative mechanism. FEBS Lett 506:173–179

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  • Maffucci T, Piccolo E, Cumashi A et al (2005) Inhibition of the phosphatidylinositol 3-kinase/Akt pathway by inositol pentakisphosphate results in antiangiogenic and antitumor effects. Cancer Res 65:8339–8349

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  • Shears SB (1998) The versatility of inositol phosphates as cellular signals. Biochim Biophys Acta 1436:49–67

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  • York JD (2006) Regulation of nuclear processes by inositol polyphosphates. Biochim Biophys Acta 1761:552–559

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Author information

Authors and Affiliations

  1. Faculty of Health Sciences, School of Biomedical Sciences, Curtin University, Rayne Building, Gower Street, Perth, WA, Australia

    Marco Falasca

Authors
  1. Marco Falasca
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Corresponding author

Correspondence to Marco Falasca .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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© 2015 Springer-Verlag Berlin Heidelberg

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Falasca, M. (2015). Pentakisphosphate. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_4438-3

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_4438-3

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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