Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Paxillin

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4412-7

Synonyms

Definition

Paxillin is an approximately 68-kDa multi-domain adapter protein featuring 5 LD motifs and 4 LIM domains. It is mainly a cytoplasmic protein enriched at focal adhesions in adherent cells but it can also translocate to the nucleus. Paxillin located at focal adhesions is one of linkers connecting extracellular matrix to the actin cytoskeleton. Paxillin is subject to tyrosine and serine/threonine phosphorylation. It is involved in cell signaling by integrins and growth factor receptors, cell adhesion and motility, and tumor growth and metastasis.

Characteristics

Structure and Binding Partners

The human paxillin gene (gene symbol: PXN) is located on chromosome 12q24.31. There are four transcript variants. Paxillin α (commonly referred to as paxillin) is encoded by the predominant transcript isoform 1 and has 557 amino acid residues (NCBI reference sequence: NP_002850.2). Paxillin is expressed ubiquitously except in platelets.

Paxillin (Fig. 1) can be roughly...

Keywords

Focal Adhesion Kinase Threonine Phosphorylation Site Alternative Translation Initiation Site Double Zinc Finger Suppress RhoA Activity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Brown MC, Turner CE (2004) Paxillin: adapting to change. Physiol Rev 84:1315–1339CrossRefPubMedGoogle Scholar
  2. Deakin NO, Turner CE (2008) Paxillin comes of age. J Cell Sci 121:2435–2444PubMedCentralCrossRefPubMedGoogle Scholar
  3. Schaller MD (2001) Paxillin: a focal adhesion-associated adaptor protein. Oncogene 20:6459–6472CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Molecular Oncology, SRB-3H. Lee Moffitt Cancer Center and Research InstituteTampaUSA