Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Pancreatic Cancer Stem Cells

  • Diane M. Simeone
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4359-4


A subpopulation of highly tumorigenic cells that possess the stem cell-like properties of the ability to self-renew and generate differentiated tumor cell types found in pancreatic cancer.


Pancreatic canceris an aggressive malignancy arising from the exocrine pancreas. Greater than 30,000 people per year are affected by the disease in the United States alone where it is the fourth leading cause of cancer death. Pancreatic cancer portends the worst prognosis of any solid tumor malignancy, with a 5-year survival rate of less than 3 %. Conventional therapies, such as chemotherapy and ionizing radiation, often produce minimal clinical response in tumor shrinkage and cancer regression. While our understanding of the molecular mechanisms underlying the development and progression has significantly improved by examining genomic and proteomic profiling of human pancreatic cancers, these studies do not account for the heterogeneity of cancer cells within a...


Pancreatic Cancer Cancer Stem Cell Pancreatic Cancer Cell Adult Stem Cell Human Pancreatic Cancer 
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  1. Al-Hajj M, Wicha M, Morrison SJ et al (2003) Prospective identification and characterization of a tumorigenic breast cancer cell. Proc Natl Acad Sci U S A 7:3983–3988CrossRefGoogle Scholar
  2. Bao S, Wu Q, Sathornsumetee S et al (2006) Stem cell-like glioblastoma cells promote tumor angiogenesis through vascular endothelial growth factor. Cancer Res 66:7843–7848CrossRefPubMedGoogle Scholar
  3. Bonnet D, Dick JE (1997) Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 3:730CrossRefPubMedGoogle Scholar
  4. Li C, Heidt DG, Dalerba P et al (2007) Identification of pancreatic cancer stem cells. Cancer Res 67:1030–1037CrossRefPubMedGoogle Scholar
  5. Reya T, Morrison SJ, Clarke MF et al (2001) Stem cells, cancer, and cancer stem cells. Nature 414:105–111CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of PhysiologyUniversity of Michigan Medical CenterAnn ArborUSA