Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Pancreatic Cancer Basic and Clinical Parameters

  • Jochen Gaedche
  • B. Michael Ghadimi
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4357-4


Epithelial malignancies of the pancreatic gland that originate in more than 85 % from ductal cells. In rare cases, tumors may also arise from acinar or endocrine cells.


Pancreatic adenocarcinoma is one of the most aggressive human malignancies reflected by a mortality rate which closely follows that of the incidence. Its incidence is steadily increasing, and today it is the fifth leading cause of cancer-related deaths in the western hemisphere. Most patients are diagnosed with pancreatic cancer in the late course of the disease with unspecific symptoms such as fatigue, weight loss, jaundice, and upper abdominal pain. At this stage pancreatic cancer frequently has invaded surrounding organs such as the duodenum and stomach and the retroperitoneal tissue and blood vessels (Fig. 1). Lymph node metastases occur in most cases and reflect a high metastatic potential.


Pancreatic Cancer Chronic Pancreatitis Hereditary Nonpolyposis Colorectal Cancer Normal Pancreatic Tissue Hereditary Pancreatitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.


  1. Baumgart M, Heinmöller E, Horstmann O et al (2005) The genetic basis of sporadic pancreatic cancer. Cell Oncol 27:3–13PubMedGoogle Scholar
  2. Evans DB, Abbruzzese JL, Rich TA (1997) Cancer of the pancreas. In: DeVita VT, Hellmann S, Rosenberg S (eds) Cancer: principles and practice of oncology, 5th edn. Lippincott, PhiladelphiaGoogle Scholar
  3. Hruban RH, Yeo CJ, Kern SE (1998) Pancreatic cancer. In: Vogelstein B, Kinzler KW (eds) The genetic basis of human cancer. Mc Graw Hill, New YorkGoogle Scholar
  4. Klöppel G (1997) Pathology and classification of tumors of the exocrine pancreas. In: Trede M, Carter DC (eds) Surgery of the pancreas. Churchill Livingstone, EdinburghGoogle Scholar
  5. Trede M, Carter JD (1997) The surgical options for pancreatic cancer. In: Trede M, Carter DC (eds) Surgery of the pancreas. Churchill Livingstone, EdinburghGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of General, Visceral and Pediatric SurgeryUniversity Medical CenterGöttingenGermany