Pancreatic Cancer Basic and Clinical Parameters
Living reference work entry
Epithelial malignancies of the pancreatic gland that originate in more than 85 % from ductal cells. In rare cases, tumors may also arise from acinar or endocrine cells.
Pancreatic adenocarcinoma is one of the most aggressive human malignancies reflected by a mortality rate which closely follows that of the incidence. Its incidence is steadily increasing, and today it is the fifth leading cause of cancer-related deaths in the western hemisphere. Most patients are diagnosed with pancreatic cancer in the late course of the disease with unspecific symptoms such as fatigue, weight loss, jaundice, and upper abdominal pain. At this stage pancreatic cancer frequently has invaded surrounding organs such as the duodenum and stomach and the retroperitoneal tissue and blood vessels (Fig. 1). Lymph node metastases occur in most cases and reflect a high metastatic potential.
KeywordsPancreatic Cancer Chronic Pancreatitis Hereditary Nonpolyposis Colorectal Cancer Normal Pancreatic Tissue Hereditary Pancreatitis
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