Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Keith SkubitzEmail author
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4344-2


Paclitaxel is an anticancer agent derived from the North America Pacific yew tree (Taxus brevifolia) that is used in the treatment of a number of common malignancies including lung, ovarian, and breast cancer.


Paclitaxel is a cancer chemotherapeutic agent that is widely used for several types of malignancies (Fig. 1a, b). It is a natural product produced from the Pacific yew tree. While first isolated from the bark of the Pacific yew, it is now commonly synthesized from a compound obtained from yew needles or cell culture systems.


Tubulin Polymerization Guanosine Triphosphate Tubulin Dimer Taxane Class Taxus Brevifolia 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Division of Hematology, Oncology and TransplantationUniversity of Minnesota Medical SchoolMinneapolisUSA