Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Paclitaxel

  • Keith Skubitz
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4344-2

Definition

Paclitaxel is an anticancer agent derived from the North America Pacific yew tree (Taxus brevifolia) that is used in the treatment of a number of common malignancies including lung, ovarian, and breast cancer.

Characteristics

Paclitaxel is a cancer chemotherapeutic agent that is widely used for several types of malignancies (Fig. 1a, b). It is a natural product produced from the Pacific yew tree. While first isolated from the bark of the Pacific yew, it is now commonly synthesized from a compound obtained from yew needles or cell culture systems.

Keywords

Tubulin Polymerization Guanosine Triphosphate Tubulin Dimer Taxane Class Taxus Brevifolia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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  3. Monzo MR, Rosell R, Sanchez JJ et al (1999) Paclitaxel resistance in non-small-cell lung cancer associated with beta-tubulin gene mutations. J Clin Oncol 17:1786–1793PubMedGoogle Scholar
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  5. Skubitz KM (1997) A phase I study of ambulatory continuous infusion paclitaxel. Anticancer Drugs 8:823–828CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Division of Hematology, Oncology and TransplantationUniversity of Minnesota Medical SchoolMinneapolisUSA