Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

P-Glycoprotein

  • Igor B. Roninson
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4341-2

Synonyms

Definition

P-glycoprotein (Pgp), the product of the human MDR1 gene responsible for a major form of multidrug resistance in tumor cells, is a transmembrane protein that carries out ATP-dependent efflux of various lipophilic compounds, including many anticancer drugs. Pgp renders tumor cells resistant to such drugs, and Pgp expression has been shown to correlate with clinical drug resistance or negative prognosis in several types of cancer.

Characteristics

The best known form of multidrug resistance in mammalian cells involves cross-resistance to a large group of lipophilic drugs with different structures and mechanisms of action. Cellular targets of such drugs include microtubules (vinblastine, vincristine, Taxol, colchicine), topoisomerase II (doxorubicin, etoposide), RNA polymerase (actinomycin D), ribosomes (puromycin), plasma membrane (gramicidin D), and mitochondria (rhodamine 6G). This multidrug resistant phenotype is due to...

Keywords

MDR1 Gene MDR1 Expression Stem Cell Marker CD34 Human MDR1 Gene Clinical Drug Resistance 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Borst P, Schinkel AH (1997) Genetic dissection of the function of mammalian P-glycoproteins. Trends Genet 13:217–222CrossRefPubMedGoogle Scholar
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  3. Johnstone RW, Ruefli AA, Smyth MJ (2000) Multiple physiological functions for multidrug transporter P-glycoprotein? Trends Biochem Sci 25:1–6CrossRefPubMedGoogle Scholar
  4. Roninson IB (1991) Molecular and cellular biology of multidrug resistance in tumor cells. Plenum Press, New YorkCrossRefGoogle Scholar
  5. Sikic BI (1997) Pharmacologic approaches to reversing multidrug resistance. Semin Hematol 34:40–47PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Molecular GeneticsSouth Carolina College of PharmacyColumbiaUSA