Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

P8 Protein

  • Cédric Malicet
  • Juan Iovanna
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4321-2

Synonyms

Definition

The p8 gene, first described as overexpressed in the pancreas during the acute phase of pancreatitis, encodes a ubiquitous nuclear and cytoplasmic stress protein. Expression of the p8 mRNA is rapid, strong, and transient in response to several stresses. The human p8 gene was assigned to chromosome 16, at position p11.2, and the gene is organized in three exons interrupted by two introns. The sizes of exons I, II, and III are 214, 150, and 329 nucleotides, respectively, and the complete mRNA sequence comprises 693 nucleotides (exclusive of the poly A tail) and has only one open reading frame.

Characteristics

The p8 gene was cloned from human, rat, mouse, and Xenopus laevis, conceptually translated from the Drosophila melanogaster genome or deduced from EST libraries (Bos taurus, Xenopus tropicalis, Zebrafish, Oryzias latipes, Bombyx mori, and Paralichthys olivaceus). p8 is a highly basic 82-aa...

Keywords

Pancreatic Cancer Stable Secondary Structure Molecular Partner Phosphorylatable Amino Secondary Structure Prediction Method 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Carracedo A, Gironella M, Lorente M et al (2006) Cannabinoids induce apoptosis of pancreatic tumor cells via reticulum endoplasmic stress-related genes. Cancer Res 66:6748–6755CrossRefPubMedGoogle Scholar
  2. Encinar JA, Mallo GV, Mizyrycki C et al (2001) Structural studies of human p8, an HMG-I/Y-like protein, with DNA binding activity modified by phosphorylation. J Biol Chem 276:2701–2707CrossRefGoogle Scholar
  3. Malicet C, Giroux V, Vasseur S et al (2006) Regulation of apoptosis by the p8/prothymosin alpha complex. Proc Natl Acad Sci U S A 103:2671–2676CrossRefPubMedPubMedCentralGoogle Scholar
  4. Valacco MP, Varone C, Malicet C et al (2006) Cell growth-dependent subcellular localization of p8. J Cell Biochem 97:1066–1079CrossRefPubMedGoogle Scholar
  5. Vasseur S, Hoffmeister A, Garcia S et al (2002) p8 is critical for tumour development induced by ras mutated protein and E1A oncogene. EMBO Rep 3:165–170CrossRefPubMedPubMedCentralGoogle Scholar

See Also

  1. (2012) ATP. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 302. doi:10.1007/978-3-642-16483-5_440Google Scholar
  2. (2012) Cell Cycle. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 737. doi:10.1007/978-3-642-16483-5_994Google Scholar
  3. (2012) High Mobility Group. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1694. doi:10.1007/978-3-642-16483-5_2729Google Scholar
  4. (2012) Pancreas. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, pp 2762–2763. doi:10.1007/978-3-642-16483-5_7055Google Scholar
  5. (2012) PEST Sequence. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2828. doi:10.1007/978-3-642-16483-5_4478Google Scholar
  6. (2012) Transcription Factor. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3752. doi:10.1007/978-3-642-16483-5_5901Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.INSERM, Stress Cellulaire, Parc Scientifique et Technologique de LuminyMarseille CedexFrance