Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Oxidative Stress

  • Jérôme Alexandre
  • Carole Nicco
  • Frederic Batteux
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4309-2

Definition

Oxidative stress is caused by an imbalance between the production of reactive oxygen and a biological system’s ability to readily detoxify the reactive intermediates or easily repair the resulting damage. It is defined as a disturbance in the prooxidant–antioxidant balance in favor of the former leading to potential damage. Oxidative stress is believed to contribute to the development of several diseases, including cancer.

Characteristics

The complex of oxidative stress involves a number of cell-chemical elements:

Free radicals include any species that contain one or more unpaired electrons, generating electrons singly occupying an atomic or molecular orbital. The presence of unpaired electrons confers a considerable degree of reactivity upon a free radical. Dioxygen is the main source of intracellular free radicals.

Reactive oxygen species (ROS) is a collective term that includes both oxygen free radicals such as superoxide anion (O2) and hydroxyl radical (OH) and other...

Keywords

Anticancer Agent Arsenic Trioxide Induce Reactive Oxygen Species Production Buthionine Sulfoximine Polyunsaturated Fatty Acid Peroxidation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Alexandre J, Nicco C, Chereau C et al (2006) Improvement of the therapeutic index of anticancer drugs by the superoxide dismutase mimic mangafodipir. J Natl Cancer Inst 98:236–244CrossRefPubMedGoogle Scholar
  2. Benhar M, Engelberg D, Levitzki A (2002) ROS, stress-activated kinases and stress signaling in cancer. EMBO Rep 3:420–425CrossRefPubMedPubMedCentralGoogle Scholar
  3. Halliwell B, Gutteridge J (1999) Free radicals in biology and medicine. Oxford University Press, New YorkGoogle Scholar
  4. Laurent A, Nicco C, Chereau C et al (2005) Controlling tumor growth by modulating endogenous production of reactive oxygen species. Cancer Res 65:948–956PubMedGoogle Scholar
  5. Nicco C, Laurent A, Chereau C et al (2005) Differential modulation of normal and tumor cell proliferation by reactive oxygen species. Biomed Pharmacother 59:169–174CrossRefPubMedGoogle Scholar

See Also

  1. (2012) Antioxidant. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 216. doi:10.1007/978-3-642-16483-5_328Google Scholar
  2. (2012) Arsenic Trioxide. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 285. doi:10.1007/978-3-642-16483-5_404Google Scholar
  3. (2012) Free Radicals. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1454. doi:10.1007/978-3-642-16483-5_2267Google Scholar
  4. (2012) MAPK. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2167. doi:10.1007/978-3-642-16483-5_3532Google Scholar
  5. (2012) Multidrug Resistance. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2393. doi:10.1007/978-3-642-16483-5_3887Google Scholar
  6. (2012) Mutagenic. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2412. doi:10.1007/978-3-642-16483-5_3909Google Scholar
  7. (2012) NADPH Oxidase. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2448. doi:10.1007/978-3-642-16483-5_3959Google Scholar
  8. (2012) NIH-3T3 Cells. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2520. doi:10.1007/978-3-642-16483-5_4084Google Scholar
  9. (2012) Superoxide Dismutase. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3563. doi:10.1007/978-3-642-16483-5_5579Google Scholar
  10. (2012) Transformation. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, pp 3757–3758. doi:10.1007/978-3-642-16483-5_5913Google Scholar
  11. (2012) VEGF. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3906. doi:10.1007/978-3-642-16483-5_6174Google Scholar
  12. (2012) Xanthine Oxidase. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3963. doi:10.1007/978-3-642-16483-5_6270Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Jérôme Alexandre
    • 1
  • Carole Nicco
    • 1
  • Frederic Batteux
    • 1
  1. 1.Faculté de Médecine Paris – DescartesUPRES 18-33, Groupe Hospitalier Cochin – Saint Vincent de PaulParisFrance