Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Oncopeptidomics

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4233-2

Definition

Oncopeptidomics is defined as application of peptidomic technologies to the field of oncology. Peptidomic technologies encompass the systematic, comprehensive multiplex analysis of native or endogenous peptides in a biological sample with respect to temporal and spatial resolution.

Characteristics

Peptides

The proteome is the set of all proteins encoded by the genome and present within an organism for a specific time frame. While the genome remains relatively stable, the proteome is remarkably dynamic with multiple mechanisms of up- and downregulation as well as different mechanisms of posttranslation modifications. One important, irreversible proteomic control mechanism is the proteolytic processing of proteins by proteases that initiate, modulate, and terminate many important cellular functions through highly specific and limited substrate cleavages. One important result of proteolytic activity is the generation of peptides. The Greek origin of the term “peptide” (from the...

Keywords

Clinical Validation Endogenous Peptide Fibrinogen Degradation Product Definitive Assessment Discriminatory Peak 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Diamandis EP (2006) Peptidomics for cancer diagnosis: present and future. J Proteome Res 5:2079–2082CrossRefPubMedGoogle Scholar
  2. Hortin GL (2006) The maldi-tof mass spectrometric view of the plasma proteome and peptidome. Clin Chem 52:1223–1237CrossRefPubMedGoogle Scholar
  3. Tammen H, Zucht HD, Budde P (2007) Oncopeptidomics – a commentary on opportunities and limitations. Cancer Lett 249:80–86CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.PXBioVisioN GmbHHannoverGermany