Oncopeptidomics is defined as application of peptidomic technologies to the field of oncology. Peptidomic technologies encompass the systematic, comprehensive multiplex analysis of native or endogenous peptides in a biological sample with respect to temporal and spatial resolution.
The proteome is the set of all proteins encoded by the genome and present within an organism for a specific time frame. While the genome remains relatively stable, the proteome is remarkably dynamic with multiple mechanisms of up- and downregulation as well as different mechanisms of posttranslation modifications. One important, irreversible proteomic control mechanism is the proteolytic processing of proteins by proteases that initiate, modulate, and terminate many important cellular functions through highly specific and limited substrate cleavages. One important result of proteolytic activity is the generation of peptides. The Greek origin of the term “peptide” (from the...