Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Oncogene Addiction

  • Andrew K. Joe
  • I. Bernard Weinstein
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4222-2

Synonyms

Definition

Oncogene addiction describes the phenomenon in which some cancers that contain multiple genetic, epigenetic, and chromosomal abnormalities remain dependent on (addicted to) one or a few genes for both maintenance of the malignant phenotype and cell survival.

Characteristics

Multistage Carcinogenesis and Oncogene Addiction

There has been considerable progress in the systemic treatment of cancer due to the rapid development and clinical application of molecular targeted agents ( Molecular Therapy). Although patients with a particular type and stage of cancer are often treated as a single group, more specific therapy is being considered, as subsets of patients who are more likely to benefit from treatment with particular agents are being identified. It is now an axiom in oncology that human cancers often evolve through a multistage process that extends over a period of decades. The marked increase in molecular biology studies has revealed that this...

Keywords

Tumor Suppressor Gene Chronic Myeloid Leukemia Enhance Cell Proliferation Molecular Target Agent EGFR Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Sawyers C (2004) Targeted cancer therapy. Nature 432:294–297CrossRefPubMedGoogle Scholar
  2. Weinstein IB (2000) Disorders in cell circuitry during multistage carcinogenesis: the role of homeostasis. Carcinogenesis 21:857–864CrossRefPubMedGoogle Scholar
  3. Weinstein IB (2002) Cancer. Addiction to oncogenes – the Achilles heel of cancer. Science 297:63–64CrossRefPubMedGoogle Scholar
  4. Weinstein IB, Joe AK (2006) Mechanisms of disease: oncogene addiction–a rationale for molecular targeting in cancer therapy. Nat Clin Pract Oncol 3:448–457CrossRefPubMedGoogle Scholar
  5. Weinstein IB et al (1997) Disorders in cell circuitry associated with multistage carcinogenesis: exploitable targets for cancer prevention and therapy. Clin Cancer Res 3:2696–2702PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of MedicineHerbert Irving Comprehensive Cancer CenterNew YorkUSA
  2. 2.Columbia UniversityNew YorkUSA