Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Oligoastrocytomas

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4203-2

Synonyms

Definition

Oligoastrocytomas are tumors located mainly in supratentorial subcortical brain areas showing composite histological features and including cells similar to oligodendrocytes or astrocytes.

Characteristics

Oligoastrocytomas and pure oligodendrogliomas constitute a subgroup of brain tumors receiving increased attention because of reports of chemosensitivity and of favorable survival rate when compared with astrocytomas. This is also reflected in the increasing rate of diagnosis of tumors with an oligodendroglial component rising from about 5 % in the past decade to approximately 15 % in present years.

The morphological borderlines between astrocytomas, oligoastrocytomas, and oligodendrogliomas are difficult and controversial issues. However the accurate distinction between these tumors has important prognostic and therapeutic implications. Patients with pure oligodendrogliomas are more likely to respond to chemotherapy and have a longer survival than...

Keywords

Diffuse Astrocytoma Oligodendroglial Component Mixed Glioma Anaplastic Oligoastrocytoma RTOG Trial 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Behin A, Hoang-Xuan K, Carpentier AF, Delattre JY et al (2003) Primary brain tumours in adults. Lancet 361:323–331CrossRefPubMedGoogle Scholar
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  3. Eoli M, Bissola L, Bruzzone MG et al (2006a) Reclassification of oligoastrocytomas by loss of heterozygosity studies. Int J Cancer 119:84–90CrossRefPubMedGoogle Scholar
  4. Eoli M, Silvani A, Pollo B et al (2006b) Molecular markers of gliomas: a clinical approach. Neurol Res 28:538–541CrossRefPubMedGoogle Scholar
  5. Gilbert MR, Lang FF (2006) Anaplastic oligodendroglial tumors: a tale of two trials. J Clin Oncol 24:2689–2690CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Unit of Clinical Neuro-OncologyIstituto Neurologico BestaMilanItaly