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Okadaic Acid

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Encyclopedia of Cancer

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Definition

Okadaic acid is a toxic polyether compound of a C38 fatty acid (Fig. 1). It is isolated from the black sponge, Halichondria okadai (Kadota), however, it is thought to be produced by marine dinoflagellates that attach to the black sponge. Okadaic is derived from the name of a Japanese educator Yaichiro Okada. When the structure of okadaic acid was elucidated in 1981, Paul Scheuer at the University of Hawaii coined the term okadaic acid for the compound in honor of Okada.

Fig. 1
figure 1

Structures of okadaic acid and its derivatives

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References

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See Also

  • Balmain A, Pragnell IB (1983) Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene. Nature 303:72-74

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Authors and Affiliations

  1. Department of Clinical Laboratory Medicine, Faculty of Medicine, Saga University, Saga 849-8501, Japan

    Hirota Fujiki

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  1. Hirota Fujiki
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Correspondence to Hirota Fujiki .

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Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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Fujiki, H. (2014). Okadaic Acid. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_4196-3

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_4196-3

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  • Online ISBN: 978-3-642-27841-9

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