Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Sai-Juan Chen
  • Guang-Biao Zhou
  • Xue-Tao Bai
  • Zhu Chen
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4163-2


Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells and mediate bidirectional nucleocytoplasmic transport, especially of mRNA and proteins. Defects in nucleoporins, e.g., overproduced or involved in chromosomal translocation, may affect nucleocytoplasmic transport and cell function, leading to cell transformation and cancer.


The Nucleocytoplasmic Transport

The nucleus is the defining feature of the eukaryotic cell. Unlike their prokaryotic counterparts, eukaryotic cells separate the nuclear synthesis of DNA and RNA from cytoplasmic protein synthesis with a barrier termed the nuclear envelope (NE). The NE is perforated by large proteinaceous assemblies, called nuclear pore complexes (NPCs), which are multiprotein channels that span the double lipid bilayer of the NE and act as the sole gatekeepers controlling the exchange of material between the two locales (Fig. 1a). In yeast, half of the NPC is made up of a core scaffold,...


Acute Myeloid Leukemia Nuclear Pore Complex Acute Lymphoid Leukemia Nucleocytoplasmic Transport Transport Machinery 
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  1. Akey CW, Radermacher M (1993) Architecture of the Xenopus nuclear pore complex revealed by three-dimensional cryo-electron microscopy. J Cell Biol 122:1–19CrossRefPubMedGoogle Scholar
  2. Alber F, Dokudovskaya S, Veenhoff LM et al (2007) The molecular architecture of the nuclear pore complex. Nature 45:695–701CrossRefGoogle Scholar
  3. Conti E, Muller CW, Stewart M (2006) Karyopherin flexibility in nucleocytoplasmic transport. Curr Opin Struct Biol 16:237–244CrossRefPubMedGoogle Scholar
  4. Gould VE, Martinez N, Orucevic A et al (2000) A novel, nuclear pore-associated, widely distributed molecule overexpressed in oncogenesis and development. Am J Pathol 157:1605–1613CrossRefPubMedPubMedCentralGoogle Scholar
  5. Kau TR, Way JC, Silver PA (2004) Nuclear transport and cancer: from mechanism to intervention. Nat Rev Cancer 4:106–117CrossRefPubMedGoogle Scholar
  6. Rout MP, Aitchison JD (2001) The nuclear pore complex as a transport machine. J Biol Chem 276:16593–16596CrossRefPubMedGoogle Scholar
  7. Rout MP et al (2000) The yeast nuclear pore complex: composition, architecture, and transport mechanism. J Cell Biol 148:635–652CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Sai-Juan Chen
    • 1
  • Guang-Biao Zhou
    • 2
  • Xue-Tao Bai
    • 1
  • Zhu Chen
    • 1
  1. 1.State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui-Jin HospitalShanghai Jiao Tong University School of MedicineShanghaiPeople’s Republic of China
  2. 2.State Key Laboratory of Membrane BiologyInstitute of Zoology, Chinese Academy of SciencesBeijingChina