Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Nucleoporin

  • Sai-Juan Chen
  • Guang-Biao Zhou
  • Xue-Tao Bai
  • Zhu Chen
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4163-2

Definition

Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells and mediate bidirectional nucleocytoplasmic transport, especially of mRNA and proteins. Defects in nucleoporins, e.g., overproduced or involved in chromosomal translocation, may affect nucleocytoplasmic transport and cell function, leading to cell transformation and cancer.

Characteristics

The Nucleocytoplasmic Transport

The nucleus is the defining feature of the eukaryotic cell. Unlike their prokaryotic counterparts, eukaryotic cells separate the nuclear synthesis of DNA and RNA from cytoplasmic protein synthesis with a barrier termed the nuclear envelope (NE). The NE is perforated by large proteinaceous assemblies, called nuclear pore complexes (NPCs), which are multiprotein channels that span the double lipid bilayer of the NE and act as the sole gatekeepers controlling the exchange of material between the two locales (Fig. 1a). In yeast, half of the NPC is made up of a core scaffold,...

Keywords

Acute Myeloid Leukemia Nuclear Pore Complex Acute Lymphoid Leukemia Nucleocytoplasmic Transport Transport Machinery 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Sai-Juan Chen
    • 1
  • Guang-Biao Zhou
    • 2
  • Xue-Tao Bai
    • 1
  • Zhu Chen
    • 1
  1. 1.State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui-Jin HospitalShanghai Jiao Tong University School of MedicineShanghaiPeople’s Republic of China
  2. 2.State Key Laboratory of Membrane BiologyInstitute of Zoology, Chinese Academy of SciencesBeijingChina