Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Nucleolin

  • Atsuko Masumi
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4160-11

Definition

Nucleolin is a ubiquitous, nonhistone nucleolar phosphoprotein of eukaryotic cells and is present in abundance in the dense fibrillar and granular regions of the nucleolus. It is also able to localize in the nucleus, in the cytoplasm, and at the cell surface. Nucleolin is a multifunctional RNA-binding protein involved in many cellular processes, including ribosome biogenesis, the processing of ribosomal RNA (rRNA), mRNA stability, transcriptional regulation, and cell proliferation; it is also a downstream target of several signal transduction pathways.

Characteristics

Regulation of Nucleolin Function as a Phosphoprotein

The multiple activities of nucleolin are regulated by covalent modifications, most notably phosphorylation, methylation, proteolysis, and ADP-ribosylation. Via phosphorylation, nucleolin function is coupled to growth control. Active rRNA transcription is positively correlated with highly phosphorylated nucleolin. In growing cells, casein kinase II (CKII)...

Keywords

Cervical Cancer Ribosome Biogenesis Cervix Uterus Cdc2 Kinase rDNA Transcription 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Ginisty H, Sicard H, Roger B et al (1999) Structure and functions of nucleolin. J Cell Sci 112:761–772PubMedGoogle Scholar
  2. Gristein E, Shan Y, Karawajew L et al (2006) Cell cycle-controlled interaction of nucleolin with the retinoblastoma protein and cancerous cell transformation. J Biol Chem 281:22223–22235CrossRefGoogle Scholar
  3. Masumi A, Fukazawa H, Shimazu T et al (2006) Nucleolin is involved in interferon regulatory factor-2-dependent transcriptional activation. Oncongene 25:5113–5124Google Scholar
  4. Srivastava M, Pollard HB (1999) Molecular dissection of nucleolin’s role in growth and cell proliferation: new insight. FASEB J 13:1911–1922PubMedGoogle Scholar
  5. Takagi M, Absalon MJ, McLure KG et al (2005) Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell 123:49–63CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Safety Research on Blood and Biological ProductsNational Institute of Infectious DiseasesTokyoJapan