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Encyclopedia of Cancer pp 1–8Cite as

Notch/Jagged Signaling

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Definition

Notch and Jagged proteins define an evolutionarily conserved signal transduction pathway that is critically important for cell fate decisions in metazoan development. Notch and Jagged are single pass membrane-spanning proteins that share a receptor/ligand relationship, respectively. Jagged is the mammalian orthologue of the Drosophila Serrate gene. Collectively, the Notch ligands are referred to as the DSL proteins (Delta/Serrate/Lag). Constitutive activation of the Notch signaling pathway by chromosomal translocation, point mutation, or gene amplification plays a role in tumor initiation and/or progression. Aberrant expression of the intracellular portion of Notch proteins (NotchIC) is associated with the oncogenic transformation of cells. Notch was linked to cancer through its frequent mutation in T-cell acute lymphoblastic leukemia (T-ALL).

Characteristics

DSL proteins are encoded by the Serrate and Delta genes. Drosophila melanogaster possess only a single Serrate, Delta...

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References

  • Ascano JM, Beverly LJ, Capobianco AJ (2003) The C-terminal PDZ-ligand of JAGGED1 is essential for cellular transformation. J Biol Chem 278:8771–8779

    Article  CAS  PubMed  Google Scholar 

  • Bray SJ (2006) Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol 7:678–689

    Article  CAS  PubMed  Google Scholar 

  • Grabher C, Boehmer H, vonLook AT (2006) Notch1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia. Nat Rev Cancer 6:347–359

    Article  CAS  PubMed  Google Scholar 

  • Hurlbut GD, Kankel MW, Lake RJ et al (2007) Crossing paths with Notch in the hyper-network. Curr Opin Cell Biol 19:166–175

    Article  CAS  PubMed  Google Scholar 

  • Kovall RA (2007) Structures of CSL, Notch and Mastermind proteins: piecing together an active transcription complex. Curr Opin Struct Biol 17:117–127

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Molecular and Cellular Oncogenesis Program, The Wistar Institute, Philadelphia, PA, USA

    Marie-Clotilde Alves-Guerra, Renée M. Demarest & Anthony J. Capobianco

Authors
  1. Marie-Clotilde Alves-Guerra
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  2. Renée M. Demarest
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  3. Anthony J. Capobianco
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Corresponding author

Correspondence to Marie-Clotilde Alves-Guerra .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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© 2015 Springer-Verlag Berlin Heidelberg

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Alves-Guerra, MC., Demarest, R.M., Capobianco, A.J. (2015). Notch/Jagged Signaling. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_4132-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_4132-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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