Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Nonsteroidal Anti-inflammatory Drugs

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4126-2

Definition

NSAIDs are a structurally diverse group of similarly acting compounds that prevent symptoms of pain, fever, and inflammation without steroid chemistry.

Characteristics

NSAIDs are the most commonly prescribed drugs worldwide for the treatment of pain and inflammation. They are effective as antipyretic and analgesic and are also effective in prevention of cardiovascular complications. In recent years, evidence from animal as well as prospective and retrospective clinical studies indicate that NSAIDs may lower the risk of cancer development and more importantly progression of cancer, especially colorectal and breast cancers.

Types of NSAIDs

Depending on their strength, duration of action, and elimination from the body, NSAIDs have been classified as:
  • Salicylic acids: aspirin, salsalate, and diflunisal

  • Acetic acids: sulindac, indomethacin, diclofenac, and tolmetin

  • Propionic acids: ibuprofen, naproxen, flurbiprofen, oxaprozin, ketoprofen, and fenoprofen

  • Enolic acids: meloxicam...

Keywords

Breast Cancer Bladder Cancer Adenomatous Polyp Mefenamic Acid Pleckstrin Homology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Biochemistry and Molecular BiologyUniversity of Texas Medical BranchGalvestonUSA