Nonsteroidal Anti-inflammatory Drugs
NSAIDs are a structurally diverse group of similarly acting compounds that prevent symptoms of pain, fever, and inflammation without steroid chemistry.
NSAIDs are the most commonly prescribed drugs worldwide for the treatment of pain and inflammation. They are effective as antipyretic and analgesic and are also effective in prevention of cardiovascular complications. In recent years, evidence from animal as well as prospective and retrospective clinical studies indicate that NSAIDs may lower the risk of cancer development and more importantly progression of cancer, especially colorectal and breast cancers.
Types of NSAIDs
Salicylic acids: aspirin, salsalate, and diflunisal
Acetic acids: sulindac, indomethacin, diclofenac, and tolmetin
Propionic acids: ibuprofen, naproxen, flurbiprofen, oxaprozin, ketoprofen, and fenoprofen
Enolic acids: meloxicam...
KeywordsBreast Cancer Bladder Cancer Adenomatous Polyp Mefenamic Acid Pleckstrin Homology
- Harris RE, Chlebowski RT, Jackson RD et al (2003) Breast cancer and nonsteroidal anti-inflammatory drugs: prospective results from the Women's Health Initiative. Cancer Res 63:6096–6101Google Scholar