Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Non-rhabdomyosarcoma Soft Tissue Sarcomas

  • Andrea Ferrari
  • Michela Casanova
  • Paola Collini
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4118-4

Synonyms

Definition

Soft tissue sarcomas (STSs) are a heterogeneous group of mesenchymal extraskeletal malignant tumors, classified on the basis of their differentiation according to the adult tissue they resemble.

While benign neoplasms of soft tissues (i.e., lipoma, fibroma, leiomyoma, hemangioma) are relatively frequent and outnumber by 100 times malignant cases (incidence of about 300 new cases per 1,00,000), malignant tumors are rare, with an incidence of around 2–3/1,00,000/year, accounting for less than 1 % of all malignant tumors and 2 % of all cancer-related deaths. However, in pediatric age, STSs represent about 8 % of all malignancies, though their absolute number is lower than in adult age.

Characteristics

In childhood and adolescence, about half of STSs are represented by rhabdomyosarcomas (RMSs), one of the most typical childhood cancers, characterized by a peak incidence between 3 and 5 years (and a second, smaller peak in adolescence). The...

Keywords

Soft Tissue Sarcoma Synovial Sarcoma Malignant Peripheral Nerve Sheath Tumor Ewing Sarcoma Epithelioid Sarcoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Ferrari A, Casanova M (2005) New concepts for the treatment of pediatric non-rhabdomyosarcoma soft tissue sarcomas. Expert Rev Anticancer Ther 5(2):307–318CrossRefPubMedGoogle Scholar
  2. Ferrari A, Casanova M, Meazza C et al (2005) Adult-type soft tissue sarcomas in pediatric age: experience at the Istituto Nazionale Tumori in Milan. J Clin Oncol 23:4021–4030CrossRefPubMedGoogle Scholar
  3. Okcu MF, Munsell M, Treuner J et al (2003) Synovial sarcoma of childhood and adolescence: a multicenter, multivariate analysis of outcome. J Clin Oncol 21:1602–1611CrossRefPubMedGoogle Scholar
  4. Okcu MF, Hicks J, Merchant TE et al (2006) Nonrhabdomyosarcomatous soft tissue sarcomas. In: Pizzo PA, Poplack DC (eds) Principles and practice of pediatric oncology, 5th edn. Lippincott Williams & Wilkins, Philadelphia, pp 1033–1073Google Scholar
  5. Spunt SL, Poquette CA, Hurt YS et al (1999) Prognostic factors for children and adolescents with surgically resected nonrhabdomyosarcoma soft tissue sarcoma: an analysis of 121 patients treated at St Jude Children’s Research Hospital. J Clin Oncol 17:3697–3705PubMedGoogle Scholar

See Also

  1. (2012) Adjuvant. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 75. doi:10.1007/978-3-642-16483-5_107Google Scholar
  2. (2012) Angiosarcoma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 187. doi:10.1007/978-3-642-16483-5_279Google Scholar
  3. (2012) Costello syndrome. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 983. doi:10.1007/978-3-642-16483-5_1347Google Scholar
  4. (2012) Doxorubicin. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1159. doi:10.1007/978-3-642-16483-5_1722Google Scholar
  5. (2012) DT40. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1168. doi:10.1007/978-3-642-16483-5_1747Google Scholar
  6. (2012) Epithelioid hemangioendothelioma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1296. doi:10.1007/978-3-642-16483-5_1964Google Scholar
  7. (2012) Fibroblasts. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1398. doi:10.1007/978-3-642-16483-5_2176Google Scholar
  8. (2012) Hemangioma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1640. doi:10.1007/978-3-642-16483-5_2613Google Scholar
  9. (2012) Leiomyoma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1999. doi:10.1007/978-3-642-16483-5_3305Google Scholar
  10. (2012) Lipoma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2056. doi:10.1007/978-3-642-16483-5_3379Google Scholar
  11. (2012) Malignant peripheral nerve sheath tumor. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2149. doi:10.1007/978-3-642-16483-5_3515Google Scholar
  12. (2012) Malignant tumor. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2150. doi:10.1007/978-3-642-16483-5_3519Google Scholar
  13. (2012) Taxanes. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 3614–3615. doi:10.1007/978-3-642-16483-5_6648Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Andrea Ferrari
    • 1
  • Michela Casanova
    • 1
  • Paola Collini
    • 2
  1. 1.Pediatric Oncology UnitFondazione IRCCS Istituto Nazionale TumoriMilanoItaly
  2. 2.Anatomic Pathology DepartmentFondazione IRCCS Istituto Nazionale TumoriMilanoItaly