Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

NKG2D Receptor

  • Werner Held
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4100-2

Synonyms

Definition

The NKG2D receptor complex mediates the elimination of distressed host cells via the activation of innate immune effector cells such as natural killer cells.

Characteristics

The NKG2D Receptor

NKG2D is a homodimeric, type II integral membrane protein, which belongs to a subfamily of C-type lectin-like receptors. The NKG2D receptor is constitutively expressed on natural killer (NK) cells, most TCRγδ T cells, and a large fraction of NK T cells where it serves as a primary activation receptor. The KLRK1 gene is located in the NK gene complex on mouse chromosome 6 or human chromosome 12. This locus harbors a significant number of C-type lectin-like receptors that are preferentially expressed in NK cells.

NKG2D is a multi-subunit receptor complex, whereby the NKG2D homodimer mediates ligand binding. Specialized adaptor molecules, which are associated non-covalently,...

Keywords

Retinoic Acid NKG2D Ligand NKG2D Receptor Natural Killer Gene Complex Established Tumor Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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  5. Smyth MJ, Swann J, Cretney EY et al (2005) NKG2D function protects the host from tumor initiation. J Exp Med 202:583–588CrossRefPubMedPubMedCentralGoogle Scholar

See Also

  1. (2012) DAP-10. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1060. doi:10.1007/978-3-642-16483-5_1514Google Scholar
  2. (2012) DAP-12. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1060. doi:10.1007/978-3-642-16483-5_1515Google Scholar
  3. (2012) ERK. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, pp 1307–1308. doi:10.1007/978-3-642-16483-5_1987Google Scholar
  4. (2012) H60. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1625. doi:10.1007/978-3-642-16483-5_2545Google Scholar
  5. (2012) Interleukin. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1892. doi:10.1007/978-3-642-16483-5_3094Google Scholar
  6. (2012) ITAM. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1921. doi:10.1007/978-3-642-16483-5_3165Google Scholar
  7. (2012) MICA, MICB. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2289. doi:10.1007/978-3-642-16483-5_3706Google Scholar
  8. (2012) P53. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2747. doi:10.1007/978-3-642-16483-5_4331Google Scholar
  9. (2012) Rae-1. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3160. doi:10.1007/978-3-642-16483-5_4931Google Scholar
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  11. (2012) Src Family Tyrosine Kinase. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3498. doi:10.1007/978-3-642-16483-5_5467Google Scholar
  12. (2012) T Cell. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3599. doi:10.1007/978-3-642-16483-5_5645Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Ludwig Center for Cancer Research, Department of OncologyUniversity of LausanneEpalingesSwitzerland