Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Neutrophil Elastase

  • Zhifu Sun
  • Ping Yang
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4054-6

Synonyms

Definition

NE is a single-chain glycoprotein with 218 amino acid residues and belongs to a member of the chymotrypsin superfamily of serine protease, which includes chymotrypsin, trypsin, and elastase. With three residues in the active site, His41-Asp88-Ser173 comprises a “charge-relay” system to carry out hydrolysis. All serine proteases have their own internal inhibitors to prevent any overdose effects of cell lysis. A natural inhibitor of NE is α1-antitrypsin (α1-AT). The major physiological function of NE is host defense, i.e., to degrade foreign microorganisms or organic molecules that were phagocytosed by neutrophils. NE also degrades a variety of substrates including elastin, the most important of all, and other extracellular matrix proteins (collagen, proteoglycan, fibronectin,...

Keywords

Chronic Myeloid Leukemia Interstitial Lung Disease Neutrophil Elastase Behcet Disease Develop Lung Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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  5. Yang P, Bamlet WR, Sun Z et al (2005) Alpha1-antitrypsin and neutrophil elastase imbalance and lung cancer risk. Chest 128(1):445–452CrossRefPubMedGoogle Scholar

See Also

  1. (2012) Adhesion molecules. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 66. doi:10.1007/978-3-642-16483-5_96Google Scholar
  2. (2012) Cadherins. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 581–582. doi:10.1007/978-3-642-16483-5_770Google Scholar
  3. (2012) Carcinogen. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 644. doi:10.1007/978-3-642-16483-5_839Google Scholar
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Health Sciences ResearchMayo Clinic College of MedicineRochesterUSA