Synonyms
Definition
Neutropenia is an inherited or acquired condition manifested by low numbers of circulating white blood cells known as neutrophils. The absolute neutrophil count (ANC) may be estimated directly or as the product of the total white blood cell count and the fraction of polymorphonuclear cells and band forms in the blood count differential and is generally expressed as the number of cells per mm3. The common toxicity criteria established by the US National Cancer Institute grade neutropenia as grade 0 for ≥2,000/mm3; grade 1 for ≥1,500–<2,000/mm3; grade 2 for ≥1,000–<1,500/mm3; grade 3 for ≥500–<1,000/mm3; and grade 4 for <500/mm3. However, the term neutropenia clinically is generally reserved for ANC <1,500/mm3 (grades 2 or greater).
Characteristics
Hematopoiesis
Normal hematopoiesis is characterized by the controlled proliferation and maturation of multiple cell lines critical to the development of the healthy individual....
References
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Infectious Diseases Society of America (2002) Guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clin Infect Dis 34:730–751
Kuderer NM, Dale D, Crawford J et al (2006) The morbidity, mortality and cost of febrile neutropenia in cancer patients. Cancer 106:2258–2266
Lyman GH, Kuderer NM, Djulbegovic B (2002) Prophylactic granulocyte colony-stimulating factor in patients receiving dose intensive cancer chemotherapy: a meta-analysis. Am J Med 112:406–411
Smith TJ, Khatcheressian J, Lyman GH et al (2006) Update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guideline. J Clin Oncol 24:3187–3205
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Lyman, G.H. (2015). Neutropenia. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_4052-2
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DOI: https://doi.org/10.1007/978-3-642-27841-9_4052-2
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Publisher Name: Springer, Berlin, Heidelberg
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