Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Akira Nakagawara
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4051-2



In normal neurons, neurotrophins and their receptors regulate growth, differentiation, and cell survival during neural development and maintaining the adult nervous tissues. Neurotrophins are composed of:
  • Nerve growth factor (NGF).

  • Brain-derived neurotrophic factor (BDNF): BDNF is a neurotrophin in the central nervous system (CNS), predominantly in the brain and the periphery. This is in contrast to NGF acting predominantly in the peripheral nervous system. It acts on certain neurons of the CNS and the peripheral nervous system that helps to support the survival of existing neurons and encourage the growth and differentiation of new neurons and synapses. In the brain, it is active in the hippocampus, cortex, and basal forebrain – areas vital to learning, memory, and higher thinking. BDNF was the second neurotrophic factor to be characterized after NGF.

  • Neurotrophin-3 (NT-3).

  • Neurotrophin-4/neurotrophin-5 (NT-4/NT-5).

In cancers,...


Acute Myeloid Leukemia Nerve Growth Factor Papillary Thyroid Carcinoma Neurotrophin Signaling p75NTR Receptor 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Saga Medical Center KOSEIKANTosuJapan