Definition
A family of peptides that comprises the neuromedins A, B, and C (bombesin-like), K (neurokinin B) and L (neurokinin A), N (neurotensin-like), S, and U.
Characteristics
This family of peptides termed “neuromedins” was initially isolated from porcine spinal cord on account of its ability to contract smooth muscle. This family of peptides currently includes the neuromedins A (NMA), B (NMB), C (NMC), K (NMK), L (NML), N (NMN), S (NMS), and U (NMU); however, their structural and functional characteristics vary greatly. These neuromedins are found in many tissues including the central nervous system as well as in the gastrointestinal tract and have been implicated in a wide variety of physiological functions as neuropeptides. Neuropeptides function peripherally as paracrine and autocrine factors to regulate diverse physiological processes and act as neurotransmitters or neuromodulators in the nervous system. In general, the receptors which mediate signaling by binding...
References
Brighton PJ, Szekeres PG, Willars GB (2004) Neuromedin U and its receptors: structure, function, and physiological roles. Pharmacol Rev 56:231–248
Heasley LE (2001) Autocrine and paracrine signaling through neuropeptide receptors in human cancer. Oncogene 20:1563–1569
Ohki-Hamazaki H (2000) Neuromedin B. Prog Neurobiol 62:297–312
See Also
(2012) Autocrine. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 311. doi: 10.1007/978-3-642-16483-5_468
(2012) Glioma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 1557. doi: 10.1007/978-3-642-16483-5_2423
(2012) Paracrine. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 2783. doi: 10.1007/978-3-642-16483-5_4380
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Daigo, Y. (2015). Neuromedin. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_4040-2
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DOI: https://doi.org/10.1007/978-3-642-27841-9_4040-2
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Publisher Name: Springer, Berlin, Heidelberg
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