Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Neuroblastoma

  • Manfred Schwab
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4026-5

Definition

Neuroblastomas are childhood embryonal tumors of migrating neuroectodermal cells, derived from the neural crest and destined for the adrenal medulla and sympathetic nervous system.

The term neuroblastoma is commonly used for all types of neuroblastic tumors. The International Neuroblastoma Pathology Committee distinguishes between four types of neuroblastic tumors:
  • Neuroblastoma (Schwannian stroma-poor)

  • Ganglioneuroblastoma, intermixed (Schwannian stroma-rich)

  • Ganglioneuroma (Schwannian stroma-dominant)

  • Ganglioneuroblastoma, nodular (composite, Schwannian stroma-rich/stroma-dominant and stroma-poor)

Characteristics

Neuroblastic tumors are the most common solid extracranial malignant tumors during the first 2 years of life. In the United States of America, seven new cases per million population per year are detected in black children and 9.6 per million in white children. More than 90 % of cases occur in the first decade of life. Neuroblastoma has been detected in the fetus...

Keywords

Neuroblastic Tumor Unfavorable Histology Prenatal Ultrasound Examination Spontaneous Maturation Paternal Occupational Exposure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Berthold F, Sahin K, Hero B et al (1997) The current contribution of molecular factors to risk estimation in neuroblastoma patients. Eur J Cancer 33:2092–2097CrossRefPubMedGoogle Scholar
  2. Schwab M, Shimada H, Joshi V et al (1999) Neuroblastic tumours of adrenal gland and sympathetic nervous system. In: Kleihues P, Cavenee WK (eds) Pathology and genetics of tumours of the nervous system. International Agency for Cancer Research, LyonGoogle Scholar
  3. Schwab M, Westermann F, Hero B et al (2003) Neuroblastoma: biology, and molecular and chromosomal pathology. Lancet Oncol 4:472–480CrossRefPubMedGoogle Scholar
  4. Shimada H, Ambros IM, Dehner LP et al (1999) Terminology and morphologic criteria of neuroblastic tumors: recommendations by the International Neuroblastoma Pathology Committee. Cancer 86:349–363CrossRefPubMedGoogle Scholar
  5. Westermann F, Henrich K-O, Wei JS et al (2007) High SKp2 expression characterizes high-risk neuroblastomas independent of MYCN status. Clin Cancer Res 13:4695–4696CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.German Cancer Research Center (DKFZ)HeidelbergGermany