Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Neoadjuvant Therapy

  • Charles L. Vogel
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4005-2



Neoadjuvant therapy is an auxiliary therapy (e.g., androgen ablation in prostate cancer) administered prior to another therapy (e.g., surgery or radiation). It is given prior to surgery in an attempt to decrease the size of the tumor. It is performed in an attempt to make the tumor easier to remove and to increase the chances that removal of the tumor is curative.


In most solid tumors, surgery remains the initial primary modality of treatment. With the increasing effectiveness of systemic therapies ( chemotherapy and hormonal therapy) in advanced disease stages and also in the postoperative “adjuvant” setting, studies were instituted in many solid tumor types using systemic therapies prior to surgery. Advantages of this approach may include:
  • Downstaging of the tumor allowing for less extensive surgery to be performed

  • Ability to...


Systemic Therapy Breast Conservation Surgery Androgen Ablation Fine Needle Aspirate Primary Systemic Therapy 
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See Also

  1. (2012) Ablation. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 14. doi: 10.1007/978-3-642-16483-5_16Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Sylvester Cancer Center, School of MedicineUniversity of MiamiPlantationUSA