Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Nemosis

  • Antti Vaheri
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_4002-2

Definition

Nemosis (from Nemesis, goddess in Greek mythology who brought justified revenge or compensation) is a newly discovered type of fibroblast activation which is thought to operate in inflammation and cancer. Experimentally, nemosis is induced when normal fibroblasts are not allowed to adhere and spread on a solid substratum but are instead forming spheroids and making cell–cell contacts. This may be achieved by placing fibroblasts, e.g., on top of agarose-coated culture wells, or growing them in hanging drops.

Characteristics

Nemosis is characterized by a massive induction of cyclooxygenase-2 (COX-2-producing prostanoids), growth factors and especially hepatocyte growth factor/scatter factor (HGF/SF), proteolytic enzymes (plasminogen activation, matrix metalloproteinasesMMP-1, MMP-10, and MT1-MMP), and proinflammatory chemokines (e.g., MIP-1α, RANTES, and IL-8) promoting leukocyte migration. In cell culture conditions, the fibroblast spheroids terminate in programmed necrosis...

Keywords

Cell Contact Tumor Cell Invasion Leukocyte Migration Plasminogen Activation Fibroblast Activation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Bizik J, Kankuri E, Ristimäki A et al (2004) Cell–cell contacts trigger programmed necrosis and induce cyclooxygenase-2 expression. Cell Death Differ 11:183–195CrossRefPubMedGoogle Scholar
  2. Kalluri R, Zeisberg M (2006) Fibroblasts in cancer. Nat Rev Cancer 6:392–401CrossRefPubMedGoogle Scholar
  3. Kankuri E, Cholujova D, Comajova M et al (2005) Induction of hepatocyte growth factor/scatter factor by fibroblast clustering directly promotes tumor invasiveness. Cancer Res 65:9914–9922CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Medicum, Faculty of MedicineUniversity of HelsinkiHelsinkiFinland