The term “natural product” is in general use for small-molecular-weight organic compounds with no known role in the primary metabolism of their producing terrestrial or marine organism of origin, which may be prokaryotic or eukaryotic. Natural products currently used as either cancer chemotherapeutic drugs or anticancer drug candidates are produced by microbes of terrestrial origin, higher plants, and marine organisms.
Parameters of Natural Products
It has been estimated that there are some 160,000 structurally defined natural products, which are based on a large number of different carbon skeletons. These compounds are the so-called secondary metabolites of organisms and are usually of restricted taxonomic distribution, since substances of a specified structural class are biosynthesized only by certain organisms. Secondary metabolites are considered to be produced for ecological reasons by organisms that are mainly immobile...
KeywordsBrentuximab Vedotin Trastuzumab Emtansine Bisindole Alkaloid Product Anticancer Agent Cancer Chemotherapeutic Drug
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