Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Natural Killer Cell Activation

  • Garnet Suck
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3975-2

Synonyms

Definition

Induction of NK cells by double-stranded RNA, soluble factors (e.g., cytokines, antibodies), or ligands expressed by pathogen-infected or malignant cells, to exert or enhance NK-mediated immune effector functions, which include cytotoxicity, cytokine release, and mobilization of the adaptive immune system.

Characteristics

Cytokine Activation of NK Cells

Cytokines are important regulators of the immune system and as such have crucial functions in regulating NK activity. Several cytokines produced by immune cells, mainly by macrophages, dendritic cells, and activated T cells, enhance NK cell cytotoxicity or stimulate NK cells to secrete cytokines. Important functions for the cytokines interleukin (IL)-2 and IL-15, which both significantly increase the killing potential of NK cells, are well established. NK stimulatory functions have been described for IL-21, a cytokine with significant sequence homology to IL-2 and IL-15. IL-21...

Keywords

Acute Myeloid Leukemia Chronic Myeloid Leukemia Granule Polarization Autologous Acute Myeloid Leukemia Resistant Target Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Notes

Acknowledgments

I would like to thank Mickey B.C. Koh, Armand Keating, and Donald R. Branch for critical reading of the manuscript.

References

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  2. North J, Bakhsh I, Marden C et al (2007) Tumor-primed human natural killer cells lyse NK-resistant tumor targets: evidence of a two-stage process in resting NK cell activation. J Immunol 178:85–94CrossRefPubMedGoogle Scholar
  3. Suck G, Branch DR, Aravena P et al (2006) Constitutively polarized granules prime KHYG-1 NK cells. Int Immunol 18:1347–1354CrossRefPubMedGoogle Scholar
  4. Tassi I, Klesney-Tait J, Colonna M (2006) Dissecting natural killer cell activation pathways through analysis of genetic mutations in human and mouse. Immunol Rev 214:92–105CrossRefPubMedGoogle Scholar
  5. Woan K, Reddy V (2007) Potential therapeutic role of natural killer cells in cancer. Expert Opin Biol Ther 7:17–29CrossRefPubMedGoogle Scholar

See Also

  1. (2012) Cytolytic Synapse. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1055. doi: 10.1007/978-3-642-16483-5_1480Google Scholar
  2. (2012) ERK. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, pp 1307–1308. doi:10.1007/978-3-642-16483-5_1987Google Scholar
  3. (2012) Hematopoietic Stem Cell Transplants. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1645. doi:10.1007/978-3-642-16483-5_2620Google Scholar
  4. (2012) Human Lymphocyte Antigen. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1754. doi:10.1007/978-3-642-16483-5_2853Google Scholar
  5. (2012) Immunoreceptor Tyrosine-based Activation Motif. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1831. doi:10.1007/978-3-642-16483-5_3007Google Scholar
  6. (2012) Integrin. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1884. doi:10.1007/978-3-642-16483-5_3084Google Scholar
  7. (2012) Interleukin. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1892. doi:10.1007/978-3-642-16483-5_3094Google Scholar
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  9. (2012) Non-Hodgkin Lymphoma. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2537. doi:10.1007/978-3-642-16483-5_4110Google Scholar
  10. (2012) Resting NK Cell. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3265. doi:10.1007/978-3-642-16483-5_5061Google Scholar
  11. (2012) Tyrosine Kinase. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3822. doi:10.1007/978-3-642-16483-5_6079Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Health Sciences AuthorityCentre for Transfusion MedicineSingaporeSingapore