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Naevoid Basal Cell Carcinoma Syndrome

  • Living reference work entry
  • First Online:
Encyclopedia of Cancer

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Synonyms

Gorlin syndrome; NBCCS

Definition

Autosomal dominant cancer predisposition syndrome which is also characterized by multiple developmental defects. Most patients with NBCCS have a heterozygous mutation in the gene encoding the Hedgehog receptor Patched. Tumors isolated from Gorlin patients generally show homozygous inactivation of Patched.

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See Also

  • (2012) Gorlin Syndrome. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1586. doi:10.1007/978-3-642-16483-5_2481.

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  • (2012) Patched. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2792. doi:10.1007/978-3-642-16483-5_4403.

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Authors and Affiliations

  1. German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Manfred Schwab

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  1. Manfred Schwab
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Correspondence to Manfred Schwab .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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Schwab, M. (2014). Naevoid Basal Cell Carcinoma Syndrome. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_3960-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_3960-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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