Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Aromatase and Its Inhibitors

  • Gauri Sabnis
  • Angela Brodie
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_395-2

Synonyms

Definition

Estrogens are involved in numerous physiological processes including the development and maintenance of the female sexual organs, the reproductive cycle, reproduction, and various other neuroendocrine functions. These hormones have crucial roles in certain disease states, particularly in mammary and endometrial hyperplasias and breast cancers.

Estrogens are biosynthesized from androgens by the cytochrome P450 enzyme complex called “aromatase” first discovered in 1955.

Characteristics

Composition

The aromatase enzyme complex is bound in the endoplasmic reticulum of the cell and is comprised of two major proteins. One protein is cytochrome P450arom, a hemoprotein that converts C19 steroids (androgens) into C18 steroids (estrogens) containing a phenolic A ring. The second protein is NADPH-cytochrome P450 reductase, which transfers reducing equivalents to cytochrome P450arom. Three moles of NADPH and three moles of oxygen are...

Keywords

Postmenopausal Woman Aromatase Inhibitor Advanced Breast Cancer Estrogen Synthesis Estrone Sulfate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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  5. Winer EP, Hudis C, Burstein HJ et al (2005) American Society of Clinical Oncology technology assessment on the use of aromatase inhibitors as adjuvant therapy for postmenopausal women with hormone receptor-positive breast cancer: status report 2004. J Clin Oncol 23:619–629CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.University of Maryland School of MedicineBaltimoreUSA