Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Myopodin

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3949-2

Synonyms

Definition

Myopodin, a zyxin-binding protein, possesses capabilities to regulate cell growth and motility. The myopodin gene, deleted in many advanced prostate cancers, is considered a tumor suppressor.

Characteristics

Myopodin is a homologue of synaptopodin. Its sequence shares six stretches of degenerative homology with synaptopodin, an actin-binding protein in glomerular podocytes and dendritic spine in nervous system. The myopodin gene is mapped to chromosome 4q25. Its mRNA sequence of 4,208 bases is translated into a protein of 80 kDa in prostate and skeletal muscle, and 95 kDa in heart muscle.

Myopodin is abundantly expressed in skeletal muscle but also expressed in organs such as prostate, heart, bladder, kidney, liver, spleen, small, and large intestines. However, it is not detected in lung, placenta, brain, leukocytes, testes, colon, ovary, thymus, stomach, thyroid, spinal cord, lymph, trachea, adrenal gland, and bone marrow.

Myopodin Gene...

Keywords

Prostate Cancer Prostate Cancer Cell Prostate Cancer Cell Line Advanced Prostate Cancer Prostate Cancer Case 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Jing L et al (2004) Expression of myopodin induces suppression of tumor growth and metastasis. Am J Pathol 164(5):1799–1806CrossRefPubMedPubMedCentralGoogle Scholar
  2. Lin F et al (2001) Myopodin, a synaptopodin homologue, is frequently deleted in invasive prostate cancers. Am J Pathol 159(5):1603–1612CrossRefPubMedPubMedCentralGoogle Scholar
  3. Weins A et al (2001) Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein. J Cell Biol 155(3):393–404CrossRefPubMedPubMedCentralGoogle Scholar
  4. Yu YP, Luo JH (2006) Myopodin-mediated suppression of prostate cancer cell migration involves interaction with zyxin. Cancer Res 66(15):7414–7419CrossRefPubMedGoogle Scholar
  5. Yu YP, Tseng GC, Luo JH (2006) Inactivation of myopodin expression associated with prostate cancer relapse. Urology 68(3):578–582CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of PathologyUniversity of PittsburghPittsburghUSA