Synonyms
Definition
Myopodin, a zyxin-binding protein, possesses capabilities to regulate cell growth and motility. The myopodin gene, deleted in many advanced prostate cancers, is considered a tumor suppressor.
Characteristics
Myopodin is a homologue of synaptopodin. Its sequence shares six stretches of degenerative homology with synaptopodin, an actin-binding protein in glomerular podocytes and dendritic spine in nervous system. The myopodin gene is mapped to chromosome 4q25. Its mRNA sequence of 4,208 bases is translated into a protein of 80 kDa in prostate and skeletal muscle, and 95 kDa in heart muscle.
Myopodin is abundantly expressed in skeletal muscle but also expressed in organs such as prostate, heart, bladder, kidney, liver, spleen, small, and large intestines. However, it is not detected in lung, placenta, brain, leukocytes, testes, colon, ovary, thymus, stomach, thyroid, spinal cord, lymph, trachea, adrenal gland, and bone marrow.
Myopodin Gene...
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References
Jing L et al (2004) Expression of myopodin induces suppression of tumor growth and metastasis. Am J Pathol 164(5):1799–1806
Lin F et al (2001) Myopodin, a synaptopodin homologue, is frequently deleted in invasive prostate cancers. Am J Pathol 159(5):1603–1612
Weins A et al (2001) Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein. J Cell Biol 155(3):393–404
Yu YP, Luo JH (2006) Myopodin-mediated suppression of prostate cancer cell migration involves interaction with zyxin. Cancer Res 66(15):7414–7419
Yu YP, Tseng GC, Luo JH (2006) Inactivation of myopodin expression associated with prostate cancer relapse. Urology 68(3):578–582
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© 2015 Springer-Verlag Berlin Heidelberg
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Yu, Y.P., Luo, JH. (2015). Myopodin. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_3949-2
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DOI: https://doi.org/10.1007/978-3-642-27841-9_3949-2
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Publisher Name: Springer, Berlin, Heidelberg
Online ISBN: 978-3-642-27841-9
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