Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Yan Ping Yu
  • Jian-Hua Luo
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3949-2



Myopodin, a zyxin-binding protein, possesses capabilities to regulate cell growth and motility. The myopodin gene, deleted in many advanced prostate cancers, is considered a tumor suppressor.


Myopodin is a homologue of synaptopodin. Its sequence shares six stretches of degenerative homology with synaptopodin, an actin-binding protein in glomerular podocytes and dendritic spine in nervous system. The myopodin gene is mapped to chromosome 4q25. Its mRNA sequence of 4,208 bases is translated into a protein of 80 kDa in prostate and skeletal muscle, and 95 kDa in heart muscle.

Myopodin is abundantly expressed in skeletal muscle but also expressed in organs such as prostate, heart, bladder, kidney, liver, spleen, small, and large intestines. However, it is not detected in lung, placenta, brain, leukocytes, testes, colon, ovary, thymus, stomach, thyroid, spinal cord, lymph, trachea, adrenal gland, and bone marrow.

Myopodin Gene...


Prostate Cancer Prostate Cancer Cell Prostate Cancer Cell Line Advanced Prostate Cancer Prostate Cancer Case 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of PathologyUniversity of PittsburghPittsburghUSA