Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Myelosuppression

  • Uwe Zangemeister-Wittke
  • Hans-Uwe Simon
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3940-2

Definition

Myelosuppression (acute suppression of the bone marrow) is the most common adverse side effect of cytotoxic anticancer therapy. It describes the decrease in the production of blood cells in the bone marrow. The bone marrow produces three types of blood cells: red blood cells (erythrocytes), white blood cells (leukocytes) (which include lymphocytes, monocytes, granulocytes), and platelets (thrombocytes). Since these cell types serve distinct and important functions, myelosuppression can be associated with moderate to severe life-threatening complications, such as anemia, increased risk of infection, and bleeding.

Characteristics

The bone marrow contains stem cellsable to reproduce and differentiate into red blood cells, white blood cells, and platelets, depending on the body’s need for replacing these cell pools. Because the proliferating precursor cells produced by stem cells are almost always in mitosis and reproduce rapidly, they are highly susceptible to cytotoxic...

Keywords

Febrile Neutropenia Granulocyte Colony Stimulate Factor Cytotoxic Therapy Immature Neutrophil Normal Cell Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Carey PJ (2003) Drug-induced myelosuppression: diagnosis and management. Drug Saf 26:691–706CrossRefPubMedGoogle Scholar
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  3. Martinelli S, Kostylina G, Niggli V et al (2006) Targeting survivin via PI3K but not c-akt/PKB by anticancer drugs in immature neutrophils. Oncogene 25:6915–6923CrossRefPubMedGoogle Scholar
  4. Salemi S, Yousefi S, Constantinescu MA et al. (2012) Autophagy is required for self-renewal and differentiation of adult human stem cells. Cell Res 22:432–435.CrossRefPubMedGoogle Scholar
  5. Zangemeister-Wittke U, Simon HU (2004) An IAP in action: the multiple roles of survivin in differentiation, immunity and malignancy. Cell Cycle 3:1121–1123CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of PharmacologyUniversity of BernBernSwitzerland