Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Joseph Lipsick
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3918-2


MYB is a family of genes related to the C-MYB proto-oncogene. The name of this gene comes from myeloblastosis, the type of leukemia caused by the V-MYB viral oncogene in chickens. All vertebrates contain three related MYB genes: C-MYB (MYB), A-MYB (MYBL1), and B-MYB (MYBL2). The fruit fly and sea urchin have only one closely related MYB gene, whereas the nematode C. elegans appears to have lost the MYB gene during evolution. Other more distantly related MYB-like genes are present in animals, plants, and fungi (Fig. 1).


Adenoid Cystic Carcinoma Tumor Suppressor Gene Product Immature Blood Cell Large Multiprotein Complex Heptad Leucine Repeat 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.


  1. Clapier D et al (2007) The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL) – the translocation defining a new T-ALL subtype in very young children. Blood 110:1251–1261CrossRefGoogle Scholar
  2. Ganter B, Lipsick JS (1999) Myb and oncogenesis. Adv Cancer Res 76:21–60CrossRefPubMedGoogle Scholar
  3. Heinrichs S et al (2013) MYBL2 is a sub-haploinsufficient tumor suppressor gene in myeloid malignancy. Elife2:e00825Google Scholar
  4. Lipsick JS (2004) synMuv verite – Myb comes into focus. Genes Dev 18:2837–2844CrossRefPubMedGoogle Scholar
  5. Paik S (2004) A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med 351:2817–2826CrossRefPubMedGoogle Scholar
  6. Persson M et al. (2009) Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck. Proc Natl Acad Sci U S A 106:18740–187444CrossRefPubMedPubMedCentralGoogle Scholar
  7. Ramkissoon LA et al. (2013) Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1. Proc Natl Acad Sci U S A 110:8188–8193CrossRefPubMedPubMedCentralGoogle Scholar
  8. Ramsay RG, Gonda TJ. MYB function in normal and cancer cells. Nat Rev Cancer. 8: 523-534Google Scholar
  9. Sadasivam S, DeCaprio JA (2103) The DREAM complex: master coordinator of cell cycle-dependent gene expression. Nat Rev Cancer 13: 585-595Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Stanford UniversityStanfordUSA