Definition
Multistep development is the stepwise development of malignant tumors by successive changes in multiple characteristics (Fig. 1).
Multistep pathway from normal cell to metastatic colon carcinoma. The rate-limiting step is postulated to be the loss of the APC gene on chromosome 5. Individuals with familial adenomatous polyposis (FAP) inherit the first mutation (APC gene) and only need to acquire a second mutation. Other individuals need to acquire both mutations in the same cell lineage. Additional genetic damage is accumulated, including loss of genes on 17p, exemplified p53, and 18q, as well as other changes. These can occur in any order and result in progressively abnormal cells, eventually capable of metastasis (Figure provided by Bert Vogelstein)
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References
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See Also
(2012) ARF. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 265. doi:10.1007/978-3-642-16483-5_383
(2012) BAX. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 350. doi: 10.1007/978-3-642-16483-5_543
(2012) DCC. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 1063–1064. doi: 10.1007/978-3-642-16483-5_1524
(2012) Deleted in colorectal carcinoma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1073. doi: 10.1007/978-3-642-16483-5_6544
(2012) FHIT. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1394. doi: 10.1007/978-3-642-16483-5_2168
(2012) Glioblastoma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1554. doi: 10.1007/978-3-642-16483-5_2421
(2012) Gorlin syndrome. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1586. doi: 10.1007/978-3-642-16483-5_2481
(2012) P53. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2747. doi: 10.1007/978-3-642-16483-5_4331
(2012) Pancreas. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 2762–2763. doi: 10.1007/978-3-642-16483-5_7055
(2012) Renal cancer. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 3225–3226. doi: 10.1007/978-3-642-16483-5_6575
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Klein, G. (2015). Multistep Development. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_3904-2
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