Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Multistep Development

  • George Klein
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3904-2

Definition

Multistep development is the stepwise development of malignant tumors by successive changes in multiple characteristics (Fig. 1).

Keywords

Familial Adenomatous Polyposis Basal Cell Carcinoma Sporadic Breast Cancer Papillary Renal Cell Carcinoma Monochromosomal Hybrid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Beckmann MW et al (1997) Multistep carcinogenesis of breast cancer and tumor heterogeneity. J Mol Med 75:429–439CrossRefPubMedGoogle Scholar
  2. Bodmer W, Bishop T, Karran P (1994) Genetic steps in colorectal cancer. Nat Genet 6:217–219CrossRefPubMedGoogle Scholar
  3. Klein G, Klein E (1985) Evolution of tumors and the impact of molecular oncology. Nature 315:190–195CrossRefPubMedGoogle Scholar
  4. Nowell PC (1976) The clonal evolution of tumor cell populations. Science 194:23–28CrossRefPubMedGoogle Scholar
  5. Weinberg RA (2007) The biology of cancer. Garland Science/Taylor Francis Group, LLC, New YorkGoogle Scholar

See Also

  1. (2012) ARF. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 265. doi: 10.1007/978-3-642-16483-5_383
  2. (2012) BAX. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 350. doi:  10.1007/978-3-642-16483-5_543
  3. (2012) DCC. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 1063–1064. doi:  10.1007/978-3-642-16483-5_1524
  4. (2012) Deleted in colorectal carcinoma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1073. doi:  10.1007/978-3-642-16483-5_6544
  5. (2012) FHIT. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1394. doi:  10.1007/978-3-642-16483-5_2168
  6. (2012) Glioblastoma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1554. doi:  10.1007/978-3-642-16483-5_2421
  7. (2012) Gorlin syndrome. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1586. doi:  10.1007/978-3-642-16483-5_2481
  8. (2012) P53. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2747. doi:  10.1007/978-3-642-16483-5_4331
  9. (2012) Pancreas. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 2762–2763. doi:  10.1007/978-3-642-16483-5_7055
  10. (2012) Renal cancer. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 3225–3226. doi:  10.1007/978-3-642-16483-5_6575

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Microbiology, Tumor and Cell BiologyKarolinska InstituteStockholmSweden