Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Arginine-Depleting Enzyme Arginine Deiminase

  • Yun-Chung Leung
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_388-2

Synonyms

ADI

Definition

Arginine deiminase (ADI; EC 3.5.3.6) is an enzyme from prokaryotes that has been used to deplete arginine in the treatment of arginine-requiring cancers.

Characteristics

To starve cancer cells through amino acid deprivation can be a strategy in cancer therapy. Specific amino acids are required for the growth of certain tumor cells, while normal cells can synthesize sufficient amounts for their own needs. For example, an enzyme called asparaginase has been used to deplete asparagine in the treatment of acute lymphoblastic leukemia and a few subtypes of non-Hodgkin lymphoma (Malignant Lymphoma, Hallmarks and Concepts) because these cancers lack asparagine synthetase and are auxotrophic for asparagine. Asparaginase degrades both asparagine and glutamine. The antitumor activity of this enzyme is due to its ability to degrade asparagine, and some of its deleterious side effects were due to its degradation of glutamine.

ADI is an enzyme that hydrolyzes arginine to...

Keywords

Renal Cell Carcinoma Polyamine Synthesis Mycoplasma Hominis Orphan Drug Status Plasma Arginine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Ascierto PA, Scala S, Castello G et al (2005) Pegylated arginine deiminase treatment of patients with metastatic melanoma: results from phase I and II studies. J Clin Oncol 23:7660–7668, Erratum in: J Clin Oncol (2006) 24:4047CrossRefPubMedGoogle Scholar
  2. Cheng PN, Lam TL, Lam WM et al (2007) Pegylated recombinant human arginase (rhArg-peg 5,000 mw) inhibits the in vitro and in vivo proliferation of human hepatocellular carcinoma through arginine depletion. Cancer Res 67:309–317CrossRefPubMedGoogle Scholar
  3. Feun L, Savaraj N (2006) Pegylated arginine deiminase: a novel anticancer enzyme agent. Expert Opin Investig Drugs 15:815–822CrossRefPubMedPubMedCentralGoogle Scholar
  4. Izzo F, Marra P, Beneduce G et al (2004) Pegylated arginine deiminase treatment of patients with unresectable hepatocellular carcinoma: results from phase I/II studies. J Clin Oncol 22:1815–1822CrossRefPubMedGoogle Scholar
  5. Shen LJ, Shen WC (2006) Drug evaluation: ADI-PEG-20 – a PEGylated arginine deiminase for arginine-auxotrophic cancers. Curr Opin Mol Ther 8:240–248PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Lo Ka Chung Centre for Natural Anti-cancer Drug Development and Department of Applied Biology and Chemical TechnologyThe Hong Kong Polytechnic UniversityHong KongChina