Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Cheng-Long Huang
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3842-3



Motility is a cellular function that leads to the translocation of the cell body through a coordinated sequence of distinct biological processes, including membrane protrusion at a leading edge, the formation of cell-substrate adhesion, the development of contractile force in the cell body, and detachment at the tail of the cell.


Cell motility is a critical feature of various physiological and pathological processes, such as development, wound healing, immunity, angiogenesis, invasion, and metastasis. It includes chemokinesis (nondirectional movement) and chemotaxis (directional movement). Cell motility is generally triggered by extracellular stimuli such as gradients of chemotactic factors. In the presence of chemoattractants, extracellular signals are transduced through cell-surface receptors which thus induce various intracellular responses, such as the polarization and reorganization of the actin...


Cell Motility Actin Filament Focal Adhesion Myosin Light Chain Myosin Light Chain Phosphatase 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Department of Second SurgeryKagawa UniversityKagawaJapan