Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Molecular Therapy

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3819-2

Definition

Molecular therapy is a therapy with compounds which are rationally targeted against certain specific molecular structures.

Characteristics

There is yet no generally accepted definition of the term molecular therapy. A frequent opinion is that molecular therapeutics target diseases on an early molecular level and thus modulate the disease at its roots. This would comprise the classic gene therapy as well as other DNA- or RNA-based strategies. However, also other nonmolecular therapeutics such as chemotherapyinteract with nucleic acids. Additionally, nucleic acid-based drugs may also interact with proteins. Therefore, it seems more useful to define molecular therapy as a strategy which specifically targets certain molecular structures, although all therapies that work have a target with some kind of molecular structure. In some cases, the target is discovered first, while in others the drug is discovered before the target. In contrast to other therapeutic concepts such as...

Keywords

Epidermal Growth Factor Receptor Chronic Myeloid Leukemia Antisense Oligonucleotide Molecular Therapy Murine mAbs 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Carter PJ (2006) Potent antibody therapeutics by design. Nat Rev Immunol 6:343–357CrossRefPubMedGoogle Scholar
  2. Cross D, Burmester JK (2006) Gene therapy for cancer treatment: past, present and future. Clin Med Res 4(3):218–227CrossRefPubMedPubMedCentralGoogle Scholar
  3. Imai K, Takaoka A (2006) Comparing antibody and small-molecule therapies for cancer. Nat Rev Cancer 6:714–727CrossRefPubMedGoogle Scholar
  4. Panowski S, Bhakta S, Raab H, Polakis P, Junutula JR (2014) Site-specific antibody drug conjugates for cancer therapy. AMbs 6(1):34–45Google Scholar
  5. Patil SD, Rhodes DG, Burgess DJ (2005) DNA-based therapeutics and DNA delivery systems: a comprehensive review. AAPS J 7(1):61–77CrossRefGoogle Scholar

See Also

  1. (2012) Small Interfering RNA. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3448. doi:10.1007/978-3-642-16483-5_5372Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Klinik für Urologie und KinderurologieAmmerland Klinik GmbHWesterstedeGermany
  2. 2.Urologikum LübeckLübeckGermany