Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Molecular Pathology

  • Mark F. Evans
  • Kumarasen Cooper
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3817-2



Molecular pathology is the study of the molecular genetic causes of abnormal cell and tissue functioning with the goal of improved disease diagnosis and treatment. As a medical discipline, molecular pathology is a specialty training that incorporates the subject matter of genetics, inherited cancers, solid tumors, neoplastic hematopathology, infectious diseases, identity testing, HLA typing, and laboratory management and impacts both anatomic and clinical pathology practice.


Historical and Clinical Background

Pathology, the study of the origin, nature, and courses of diseases, has its foundation in the studies of Giovanni Battista Morgagni of Padua (1682–1771) (the “father of anatomic pathology”) and Rudolf Virchow of Berlin (1821–1902) (the “father of cellular pathology”). Dr. Morgagni documented the relationship between diseases and the gross changes observed in autopsy specimens, and Dr. Virchow established the correlation of...


Synovial Sarcoma Desmoplastic Small Round Cell Tumor Reverse Line Blot Assay Retinoic Acid Receptor Alpha Gene Preinvasive Cervical Lesion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.


  1. Calin GA, Croce C (2006) MicroRNA signatures in human cancers. Nat Rev Cancer 68:57–866Google Scholar
  2. Feinberg AP, Ohlsson R, Henikoff S (2006) The epigenetic progenitor origin of cancer. Nat Rev Cancer 7:21–33CrossRefGoogle Scholar
  3. Leonard DG (ed) (2007) Molecular pathology in clinical practice, 1st edn. Springer, New YorkGoogle Scholar
  4. Simpson PT, Reis-Filho JSR, Gale T et al (2005) Molecular evolution of breast cancer. J Pathol 205:248–254CrossRefPubMedGoogle Scholar
  5. Sjoblom T, Jones S, Wood LD et al (2006) The consensus coding sequences of human breast and colorectal cancers. Science 314:268–274CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Pathology and Laboratory MedicineUniversity of VermontBurlingtonUSA
  2. 2.Pathology and Laboratory MedicinePerelman School of Medicine at the University of PennsylvaniaPhiladelphiaUSA