Definition
Modular transporters are engineered polypeptides consisting of several interchangeable parts or modules designed for delivery of anticancer drugs to the target cancer cell and its specific subcellular compartment.
Modular transporters can also be considered as nanomedical drug vehicles (nanotechnology), which recognize the cancer cells of choice and, once in those cells, are transported to the most sensitive compartment of the cell (e.g., nucleus).
In order to reach the desired compartment of the cancer cell, the modular transporters are first passively delivered to the surface of the cell in the bloodstream. Once within the cell, depending upon the nature of the polypeptide modules, they are transported to a particular subcellular compartment utilizing the cell’s intrinsic transport machinery.
Characteristics
Objectives
To minimize side effects, many antitumor agents need to be delivered (...
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References
Gilyazova DG, Rosenkranz AA, Gulak PV et al (2006) Targeting cancer cells by novel engineered modular transporters. Cancer Res 66:10534–10540
Slastnikova TA, Rosenkranz AA, Gulak PV et al (2012) Modular nanotransporters: a multipurpose in vivo working platform for targeted drug delivery. Int J Nanomedicine 7:467–482
Slastnikova TA, Rosenkranz AA, Zalutsky MR, Sobolev AS (2015) Modular nanotransporters for targeted intracellular delivery of drugs: folate receptors as potential targets. Curr Pharm Design 21:1227–1238
Urieto JO, Liu TF, Black JH et al (2004) Expression and purification of the recombinant diphtheria fusion toxin DTIL3 for phase I clinical trials. Protein Expr Purif 33:123–133
See Also
(2012) Alpha-Particles. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer, Berlin/Heidelberg, p 147. doi: 10.1007/978-3-642-16483-5_208
(2012) Importins. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1836. doi: 10.1007/978-3-642-16483-5_3017
(2012) Ligands. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2040. doi: 10.1007/978-3-642-16483-5_3352
(2012) Module. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2354. doi: 10.1007/978-3-642-16483-5_3806
(2012) Photosensitizer. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 2881-2882. doi: 10.1007/978-3-642-16483-5_4559
(2012) Polypeptide. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2955. doi: 10.1007/978-3-642-16483-5_4676
(2012) Radionuclide. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3154. doi: 10.1007/978-3-642-16483-5_4921
(2012) Subcellular Compartments. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3552. doi: 10.1007/978-3-642-16483-5_5548
(2012) Tyrosine Kinase Receptors. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3824. doi: 10.1007/978-3-642-16483-5_6081
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Sobolev, A.S. (2014). Modular Transporters. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_3805-2
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DOI: https://doi.org/10.1007/978-3-642-27841-9_3805-2
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