Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Mitogen-Inducible Gene 6 in Cancer

  • Yu-Wen Zhang
  • George Vande Woude
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3771-2

Synonyms

Definition

Mitogen-inducible gene 6 (MIG-6) – also known as gene-33, receptor-associated late transducer (RALT), or ErbB receptor feedback inhibitor 1 (Errfi1) – is an immediate early response gene whose expression can be rapidly induced by growth factors, serum, and many stress stimuli. The MIG-6 gene locus is mapped to human chromosome 1p36.12–33 and in the mouse to the distal region of chromosome 4. Human MIG-6 encodes a 58-kDa protein consisting of 462 amino acids (461 amino acids for its mouse counterpart).

Characteristics

Mig-6 is expressed in many organs and tissues, with high-level expression in the liver and kidney and moderate levels in the lung and brain. The expression of Mig-6 is robustly regulated at the transcriptional level, and it peaks after serum induction at mid-G1 during cell cycle progression. Many growth factors such as EGF, FGF, and HGF/SF rapidly induce its expression through the activation of the RAS-MEK-ERK pathway (MAP Kinase).

Mig-6 is a...

Keywords

Squamous Cell Carcinoma Cell Line Epidermal Growth Factor Receptor Ligand Human Chromosome 1p36 Regulate Signal Transduction EGFR Inhibitor Gefitinib 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Anastasi S, Fiorentino L, Fiorini M et al (2003) Feedback inhibition by RALT controls signal output by the ErbB network. Oncogene 22:4221–4234CrossRefPubMedGoogle Scholar
  2. Anastasi S, Sala G, Huiping C et al (2005) Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin. Oncogene 24:4540–4548CrossRefPubMedGoogle Scholar
  3. Ferby I, Reschke M, Kudlacek O et al (2006) Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation. Nat Med 12:568–573CrossRefPubMedGoogle Scholar
  4. Zhang YW, Vande Woude GF (2007) Mig-6, signal transduction, stress response, and cancer. Cell Cycle 6:507–513CrossRefPubMedGoogle Scholar
  5. Zhang YW, Staal B, Su Y et al (2007) Evidence that MIG-6 is a tumor-suppressor gene. Oncogene 26:269–276CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of OncologyGeorgetown University Medical CenterWashingtonUSA
  2. 2.Van Andel Research InstituteGrand RapidsUSA