Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Mitogen-Inducible Gene 6 in Cancer

  • Yu-Wen Zhang
  • George Vande Woude
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3771-2



Mitogen-inducible gene 6 (MIG-6) – also known as gene-33, receptor-associated late transducer (RALT), or ErbB receptor feedback inhibitor 1 (Errfi1) – is an immediate early response gene whose expression can be rapidly induced by growth factors, serum, and many stress stimuli. The MIG-6 gene locus is mapped to human chromosome 1p36.12–33 and in the mouse to the distal region of chromosome 4. Human MIG-6 encodes a 58-kDa protein consisting of 462 amino acids (461 amino acids for its mouse counterpart).


Mig-6 is expressed in many organs and tissues, with high-level expression in the liver and kidney and moderate levels in the lung and brain. The expression of Mig-6 is robustly regulated at the transcriptional level, and it peaks after serum induction at mid-G1 during cell cycle progression. Many growth factors such as EGF, FGF, and HGF/SF rapidly induce its expression through the activation of the RAS-MEK-ERK pathway (MAP Kinase).

Mig-6 is a...


Squamous Cell Carcinoma Cell Line Epidermal Growth Factor Receptor Ligand Human Chromosome 1p36 Regulate Signal Transduction EGFR Inhibitor Gefitinib 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of OncologyGeorgetown University Medical CenterWashingtonUSA
  2. 2.Van Andel Research InstituteGrand RapidsUSA