Mitogen-Inducible Gene 6 in Cancer
Mitogen-inducible gene 6 (MIG-6) – also known as gene-33, receptor-associated late transducer (RALT), or ErbB receptor feedback inhibitor 1 (Errfi1) – is an immediate early response gene whose expression can be rapidly induced by growth factors, serum, and many stress stimuli. The MIG-6 gene locus is mapped to human chromosome 1p36.12–33 and in the mouse to the distal region of chromosome 4. Human MIG-6 encodes a 58-kDa protein consisting of 462 amino acids (461 amino acids for its mouse counterpart).
Mig-6 is expressed in many organs and tissues, with high-level expression in the liver and kidney and moderate levels in the lung and brain. The expression of Mig-6 is robustly regulated at the transcriptional level, and it peaks after serum induction at mid-G1 during cell cycle progression. Many growth factors such as EGF, FGF, and HGF/SF rapidly induce its expression through the activation of the RAS-MEK-ERK pathway (MAP Kinase).