Synonyms
Definition
Cell migration can be defined as the movement of cells from one site to another and is a central process in the development and homeostasis of multicellular organisms. The orchestrated movement of cells in a particular direction to a specific location is essential for tissue formation during embryonic development, wound healing, and immune responses. Deregulation of cell migration during any of these processes has serious consequences and can contribute to mental retardation, vascular disease, rheumatoid arthritis, tumor formation, and metastasis.
Characteristics
Cell migration (the movement of cells from one site to another) is an essential process for normal development and homeostasis that can also contribute to important pathologies such as neoplasia. For example, one of the major mechanisms involved in tumor cell invasionis cell migration, a process in which cells demonstrating higher invasive capacity typically show higher...
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References
Hall A (2005) Rho GTPases and the control of cell behaviour. Biochem Soc Trans 33:891–895
Lauffenburger DA, Horwitz AF (1996) Cell migration: a physically integrated molecular process. Cell 84:359–369
Raftopoulou M, Hall A (2004) Cell migration: Rho GTPases lead the way. Dev Biol 265:23–32
Ridley AJ, Schwartz MA, Burridge K et al (2003) Cell migration: integrating signals from front to back. Science 302:1704–1709
Salhia B, Tran NL, Symons M et al (2006) Molecular pathways triggering glioma cell invasion. Expert Rev Mol Diagn 6:613–626
Further Reading
(2012) Actin. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, pp 18–19. doi:10.1007/978-3-642-16483-5_42
(2012) Extracellular matrix. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1362. doi:10.1007/978-3-642-16483-5_2067
(2012) Filipodia. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1407. doi:10.1007/978-3-642-16483-5_2189
(2012) Focal contact. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1440. doi:10.1007/978-3-642-16483-5_2230
(2012) Glioma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1557. doi:10.1007/978-3-642-16483-5_2423
(2012) Integrin. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1884. doi:10.1007/978-3-642-16483-5_3084
(2012) Lamellipodia. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1971. doi:10.1007/978-3-642-16483-5_3267
(2012) Medullary breast carcinoma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2199. doi:10.1007/978-3-642-16483-5_3599
Acknowledgment
This work was supported by a grant from the Canadian Institutes of Health Research (CIHR MOP-74610).
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Rutka, J.T., Salhia, B. (2014). Migration. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_3746-2
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DOI: https://doi.org/10.1007/978-3-642-27841-9_3746-2
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Publisher Name: Springer, Berlin, Heidelberg
Online ISBN: 978-3-642-27841-9
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