Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Metastasis Suppressor Gene

  • Danny R. Welch
  • Ken Sasaki
  • Gada Al-Ani
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3673-2

Definition

Metastasis suppressors are a family of molecules functionally defined by their ability to block metastasis without blocking primary tumor growth. The suppressing activity could be the result of alterations at any of the steps in the multistep metastatic cascade.

Characteristics

To fully understand metastasis suppressors, it is first important to define a number of terms associated with carcinogenesis, tumor progression, invasion, and metastasis. Tumorigenesis refers to the acquired capacity of cells to proliferate in the absence of persistent stimulation by triggering carcinogenic agent(s). Tumor progression is the evolution of tumorigenic cells toward increasing malignancy. Invasion involves migration away from the primary tumor mass, involves breakdown of basement membranes, and usually involves secretion of proteinases. Metastasisis the process by which a malignant neoplastic cell(s) spreads to discontiguous sites and establishes secondary masses. In order to...

Keywords

Cancer Stem Cell Inflammatory Breast Cancer Betulinic Acid Vasculogenic Mimicry Metastasis Suppressor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Bohl CR, Harihar S, Denning WL, Sharma R, Welch DR (2014) Metastasis suppressors in breast cancer: mechanistic insights and clinical potential. J Mol Med (Berl) 92(1):13–30CrossRefGoogle Scholar
  2. Eccles SA, Welch DR (2007) Metastasis: recent discoveries and novel therapeutic strategies. Lancet 369:1742–1757. doi:10.1016/S0140-6736(07)60781-8PubMedCentralCrossRefPubMedGoogle Scholar
  3. Liu W, Vivian CJ, Brinker AE, Hampton KR, Lianidou E, Welch DR (2014) Microenvironmental influences on metastasis suppressor expression and function during a metastatic cell’s journey. Cancer Microenviron. doi:10.1007/s12307-014-0148-4954-63/s12307-014-0148-4Google Scholar

See Also

  1. (2012) Beta-catenin. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 385. doi:10.1007/978-3-642-16483-5_889Google Scholar
  2. (2012) BH3-interacting death domain agonist. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 389. doi:10.1007/978-3-642-16483-5_601Google Scholar
  3. (2012) Drg-1. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1160. doi:10.1007/978-3-642-16483-5_1730Google Scholar
  4. (2012) Experimental metastasis. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 1361. doi:10.1007/978-3-642-16483-5_2062Google Scholar
  5. (2012) Lung colony formation assay. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2115. doi:10.1007/978-3-642-16483-5_3436Google Scholar
  6. (2012) Macrometastasis. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2130. doi:10.1007/978-3-642-16483-5_3483Google Scholar
  7. (2012) Malignant tumor. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2150. doi:10.1007/978-3-642-16483-5_3519Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg (outside the USA) 2015

Authors and Affiliations

  1. 1.Department of Cancer Biology and the University of Kansas Cancer CenterThe University of Kansas Medical CenterKansas CityUSA