Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Mesoblastic Nephroma

  • Rhoikos Furtwängler
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3644-2

Synonyms

Definition

Mesoblastic nephroma is a rare mesenchymal tumor of the kidney, which typically occurs in neonates and young infants and constitutes the most frequent renal tumor in the first 3 months of life.

Characteristics

Mesoblastic nephroma (MN) is a rare malignant tumor of the kidney, which originates from the mesenchymal anlage (metanephrogenic blastema). The typical patient is a neonate or young infant. In the first 3 months of life, MN is the most frequent renal tumor; hence, preoperative chemotherapy is not recommended for renal tumors in this age group. It accounts for 5 % of all childhood renal tumors. According to the German Childhood Cancer Registry, the cumulative incidence of MN is estimated at 1 in 150,000 children (0–14 years) in Germany. Contrary to nephroblastoma, MN has a 2–1...

Keywords

Renal Tumor Rhabdoid Tumor Hippo Pathway Clear Cell Sarcoma Cystic Nephroma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Furtwaengler R, Reinhard H, Schenk I et al (2006) Mesoblastic nephroma – a report from the Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH). Cancer 106:2275–2283CrossRefPubMedGoogle Scholar
  2. Gadd S, Beezhold P, Jennings L et al (2012) Mediators of receptor tyrosine kinase activation in infantile fibrosarcoma: a Children’s Oncology Group study. J Pathol 22:119–130Google Scholar
  3. Knezevich SR, Garnett MJ, Pysher TJ et al (1998) ETV6-NTRK3 gene fusions and trisomy 11 establish a histogenetic link between mesoblastic nephroma and congenital fibrosarcoma. Cancer Res 58:5046–5048PubMedGoogle Scholar
  4. Schenk JP, Schrader C, Furtwaengler R (2005) MRI-morphology and staging of congenital mesoblastic nephroma: evaluation of a collection with 20 patients. RöFo 177:1373–1379PubMedGoogle Scholar
  5. Vujanic GM, Sandstedt B, Harms D et al (2002) Revised International Society of Paediatric Oncology (SIOP) working classification of renal tumors of childhood. Med Pediatr Oncol 38:79–82CrossRefPubMedGoogle Scholar

See Also

  1. Clear cell sarcoma of the kidney. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 880. doi:10.1007/978-3-642-16483-5_1210Google Scholar
  2. Metanephrogenic blastema. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 2259. doi:10.1007/978-3-642-16483-5_3668Google Scholar
  3. SIOP. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer, Berlin/Heidelberg, p 3413. doi:10.1007/978-3-642-16483-5_5319Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Universitätsklinikum des Saarlandes, Klinik für Pädiatrische Onkologie und HämatologieHomburg/SaarGermany