Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

Melanoma Antigens

  • Tobias Peikert
  • Ulrich Specks
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3610-2

Synonyms

Definition

Melanoma antigens are a group of tumor antigens. Proteasomal cleavage of these intracellular proteins generates small antigenic peptides. The presentation of these peptides in conjunction with major histocompatibility complex (MHC) molecules facilitates an immune response promoting the destruction of the melanoma antigen-expressing cancer cells.

Characteristics

Background

Over the years, several reports have documented cancer patients mounting immune responses against their malignancies. Most of these cases are characterized by massive lymphocytic infiltration of the tumor tissue, which leads to the destruction of the malignant cells and eventually to either partial or complete disease remission. Compared to other human malignancies, these immunologic phenomena are most frequently observed in malignant melanomas. This observation led researchers to focus their investigations on this particular tumor. Following experiments documenting...

Keywords

Major Histocompatibility Complex Major Histocompatibility Complex Class Synovial Sarcoma Major Histocompatibility Complex Molecule Melanoma Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access.

References

  1. Boon T, Coulie PG, Van den Eynde BJ et al (2006) Human T cell responses against melanoma. Annu Rev Immunol 24:175–208CrossRefPubMedGoogle Scholar
  2. Chomez P, De Backer O, Bertrand M et al (2001) An overview of the MAGE gene family with the identification of all human members of the family. Cancer Res 61:5544–5551PubMedGoogle Scholar
  3. Forslund KO, Nordqvist K (2001) The melanoma antigen genes – any clues to their functions in normal tissues? Exp Cell Res 265:185–194CrossRefGoogle Scholar
  4. Van der Bruggen P, Traversari C, Chomez P et al (1991) A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science 254:1643–1647CrossRefPubMedGoogle Scholar
  5. Van der Bruggen P, Stroobant V, Van Pel A et al (2006) Peptide database of T-cell defined tumor antigens. http://www.cancerimmunity.org/peptidedatabase/Tcellepitopes.htm

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Division of Pulmonary and Critical Care Medicine, Department of Internal MedicineMayo Clinic College of MedicineRochesterUSA