Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

MAP Kinase

  • Rony Seger
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3530-2

Definition

Mitogen-activated protein (MAP) kinases are a family of protein kinases that mediate the transfer of phosphate from ATP to various proteins. They are evolutionarily conserved from yeast to mammals and are expressed in nematodes, insects, slime molds, and plants as well. Moreover, the MAP kinases are ubiquitous enzymes, which are highly expressed in all cells of eukaryotic organisms. These kinases, operating within intracellular signaling pathways, play a key role in the transmission of extracellular signals from the plasma membrane to the nucleus. The MAP kinases respond to a wide array of extracellular agents, including mitogens, hormones, and cytokines, to regulate a variety of cellular responses such as proliferation, differentiation, adhesion, stress response, and apoptosis.

Characteristics

In order to survive and perform their functions, cells need to respond to many extracellular signals such as mitogens, hormones, cytokines, physical changes of the environment, and...

Keywords

Kinase Cascade Activation Loop MAPK Cascade Dual Specificity Phosphatase Extracellular Agent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Avruch J (2007) MAP kinase pathways: the first twenty years. Biochim Biophys Acta 1773:1150–1160CrossRefPubMedPubMedCentralGoogle Scholar
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  5. Shaul YD, Seger R (2007) The MEK/ERK cascade: from signaling specificity to diverse functions. Biochim Biophys Acta 1773:1213–1226CrossRefPubMedGoogle Scholar

See Also

  1. (2012) Cellular transformation assay. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 743. doi:10.1007/978-3-642-16483-5_1020Google Scholar
  2. (2012) C-Myc. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 886. doi:10.1007/978-3-642-16483-5_1232Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of Biological RegulationThe Weizmann Institute of ScienceRehovotIsrael