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APC Gene in Familial Adenomatous Polyposis

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Encyclopedia of Cancer

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Synonyms

AAPC; Adenomatous polyposis coli; APC; Attenuated adenomatous polyposis coli; Familial adenomatous polyposis; Familial polyposis coli; FAP; FPC; Gardner syndrome; GS

Definition

Familial adenomatous polyposis (FAP) is a dominant condition predisposing to the development of multiple colorectal adenomas (polyps) during adolescence. Adenomatous polyps are benign tumors that can degenerate into malignant adenocarcinomas and subsequently into metastases if the affected segment of the bowel is not surgically resected (Fig. 1a, b).

Fig. 1
figure 1

(a) Macroscopic detail of adenomatous polyps from an FAP patient; (b) section of an adenomatous polyp; HE staining (Courtesy of Dr. Alex Kartheuser, Brussels, Belgium)

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References

  • Bussey HJR (1975) Familial polyposis coli. The John Hopkins University Press, Baltimore

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See Also

  • (2012) CHRPE. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 856. doi: 10.1007/978-3-642-16483-5_1162

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  • (2012) Osteoma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 2663. doi: 10.1007/978-3-642-16483-5_4282

    Google Scholar 

  • (2012) Penetrance. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 2806. doi: 10.1007/978-3-642-16483-5_4437

    Google Scholar 

  • (2012) Wnt. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 3953. doi: 10.1007/978-3-642-16483-5_6255

    Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands

    Riccardo Fodde

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  1. Riccardo Fodde
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Correspondence to Riccardo Fodde .

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Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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Fodde, R. (2015). APC Gene in Familial Adenomatous Polyposis. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_349-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_349-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

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