Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab

APC Gene in Familial Adenomatous Polyposis

Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_349-2

Synonyms

Definition

Familial adenomatous polyposis (FAP) is a dominant condition predisposing to the development of multiple colorectal adenomas (polyps) during adolescence. Adenomatous polyps are benign tumors that can degenerate into malignant adenocarcinomas and subsequently into metastases if the affected segment of the bowel is not surgically resected (Fig. 1a, b).

Keywords

Familial Adenomatous Polyposis Adenomatous Polyposis Coli Desmoid Tumor Familial Adenomatous Polyposis Patient Adenomatous Polyposis Coli Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

  1. Bussey HJR (1975) Familial polyposis coli. The John Hopkins University Press, BaltimoreGoogle Scholar
  2. Fodde R, Khan P (1995) Genotype–phenotype correlations at the adenomatous polyposis coli (APC) gene. Crit Rev Oncog 6:291–303CrossRefPubMedGoogle Scholar
  3. Polakis P (1995) Mutations in the APC gene and their implications for protein structure and function. Curr Opin Genet Dev 5:66–71CrossRefPubMedGoogle Scholar
  4. Polakis P (1997) The adenomatous polyposis coli (APC) tumor suppressor. Biochim Biophys Acta 1332:F127–F147PubMedGoogle Scholar
  5. Talbot IC (1994) Pathology. In: Robin ADS, Phillips KS, Thomson JPS (eds) Familial polyposis and other polyposis syndromes. Edward Arnold, London/Boston/Melbourne/Auckland, pp 15–25Google Scholar

See Also

  1. (2012) CHRPE. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 856. doi: 10.1007/978-3-642-16483-5_1162Google Scholar
  2. (2012) Osteoma. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 2663. doi: 10.1007/978-3-642-16483-5_4282Google Scholar
  3. (2012) Penetrance. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 2806. doi: 10.1007/978-3-642-16483-5_4437Google Scholar
  4. (2012) Wnt. In: Schwab M (ed) Encyclopedia of cancer, 3rd edn. Springer Berlin Heidelberg, p 3953. doi: 10.1007/978-3-642-16483-5_6255Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.Department of PathologyJosephine Nefkens Institute, Erasmus MCRotterdamThe Netherlands