Encyclopedia of Cancer

Living Edition
| Editors: Manfred Schwab


  • Jeffrey W. Pollard
Living reference work entry
DOI: https://doi.org/10.1007/978-3-642-27841-9_3487-2



Mononuclear phagocytic cells differentiated from yolk sac, fetal liver and bone marrow progenitors found in all tissues.


Macrophages originally defined by their phagocytic ability, hence their name (large eater), are one of the major cell types in the body and are found in all tissues where they often constitute 10–20 % of the cells. These phagocytic cells were initially defined as being members of the reticular-endothelial system (RES) however, this included cells that would not normally be considered macrophages. Thus the RES definition was replaced in the 1960s by the mononuclear phagocytic system (MPS) where adult tissue resident macrophages were suggested to be derived from circulating monocytes produced in the bone marrow (BM). Despite this still extant definition of macrophages, recent research have indicated that it is inadequate since most...


Vascular Endothelial Growth Factor Mononuclear Phagocyte Inflammatory Monocyte Myeloid Suppressor Cell Promote Tumor Cell Survival 
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See also

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  3. (2012) Granulocyte-Macrophage Colony-Stimulating Factor. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 1597. doi:10.1007/978-3-642-16483-5_6778Google Scholar
  4. (2012) Myeloid Suppressor Cells. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 2437. doi:10.1007/978-3-642-16483-5_3937Google Scholar
  5. (2012) VEGF. In: Schwab M (ed) Encyclopedia of Cancer, 3rd edn. Springer Berlin Heidelberg, p 3906. doi:10.1007/978-3-642-16483-5_6174Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  1. 1.MRC Centre for Reproductive Health, Queen’s Medical Research InstituteThe University of EdinburghEdinburghUK
  2. 2.Department of Developmental and Molecular BiologyAlbert Einstein College of MedicineNew YorkUSA