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Encyclopedia of Cancer pp 1–3Cite as

Macrophage-Stimulating Protein

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Synonyms

DNF15S2; Hepatocyte growth factor-like protein; HGFL; Macrophage-stimulating protein; MSP; MST1

Definition

MSP is a plasminogen-related growth and motility serum protein that was discovered as a macrophage chemotactic factor (Fig. 1).

Fig. 1
figure 1

Structure and conversion of pro-MSP to MSP. MSP comprises an N-terminal domain (N) which includes a hairpin loop, four kringle domains (K1–K4), and a serine proteinase-like domain (SP). The interchain disulfide bridge is formed by the α chain Cys468 and the β chain Cys588 (solid circles connected by –S–S–). MSP circulates in the blood as single-chain biologically inactive pro-MSP. At extravascular sites, trypsin-like proteases convert pro-MSP to biologically active, disulfide-linked, and αβ heterodimeric MSP by cleavage of the peptide bond between Arg483 and Val484 (shown as solid circles)

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References

  • Danilkovitch A, Leonhard EJ (1999) Kinases involved in MSP/RON signaling. J Leukoc Biol 65:345–348

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  • Leonard EJ, Skeel A (1976) A serum protein that stimulates macrophage movement, chemotaxis and spreading. Exp Cell Res 102:434–438

    Article  CAS  PubMed  Google Scholar 

  • Leonhard EJ (1997) Biological aspects of macrophage stimulating protein (MSP) and its receptor. Ciba Found Symp 212:183–191

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  • Leonhard EJ, Danilkovitch A (2000) Macrophage stimulating protein. Adv Cancer Res 77:139–167

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Authors and Affiliations

  1. National Cancer Institute-FCRDC, Frederick, MD, USA

    Alla Danilkovitch-Miagkova

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  1. Alla Danilkovitch-Miagkova
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Correspondence to Alla Danilkovitch-Miagkova .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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Danilkovitch-Miagkova, A. (2015). Macrophage-Stimulating Protein. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_3486-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_3486-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

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